Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Model for Prediction of Cisplatin Induced Nephrotoxicity by Kidney Weight in Experimental Rats



Nematbakhsh M1, 2, 3 ; Ashrafi F1, 4 ; Nasri H1, 3, 4 ; Talebi A1, 5 ; Pezeshki Z1 ; Eshraghi F1 ; Haghighi M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Hematology Oncology Division of Departments of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2013

Abstract

Background: Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. Cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (Cr) and blood urea nitrogen (BUN). This study was designed to find out a model for prediction of cisplatin induced nephrotoxicity. Materials and Methods: Pathological damage score, kidney weight, BUN, and Cr of 227 rats that were involved in different projects were determined. A total of 187 rats were treated with 7 mg/kg cisplatin and sacrificed 1 week later. Results: There was a good significant correlation between normalized kidney weight and logarithmic scale of BUN and Cr. Relationship between BUN, Cr or normalized kidney weight and pathology damage score was significant. Conclusion: Normalized kidney weight and pathology damage score is a good predictor of renal function in cisplatin induced nephrotoxicity in experimental rats.
Related Docs
View other Related Docs
1. Cisplatin-Induced Renal Toxicity: A Short Review, Life Science Journal (2014)
2. Vacuolization, Dilatation, Hyaline Cast, Debris or Degeneration: Which One Is the Most Correlated Item to Score the Kidney Damage Pathologically in Cisplatin Induced Nephrotoxicity Model?, Nephro-Urology Monthly (2013)
3. Age and Gender Related Renal Side Effects of Cisplatin in Animal Model, Asian Pacific Journal of Cancer Prevention (2017)
4. Administration of Vitamin E and Losartan As Prophylaxes in Cisplatin-Induced Nephrotoxicity Model in Rats, Journal of Nephrology (2012)
5. Time Course of Cisplatin-Induced Nephrotoxicity and Hepatotoxicity, Journal of Nephropathology (2017)
6. The Role of Magnesium Supplementation in Cisplatin-Induced Nephrotoxicity in a Rat Model: No Nephroprotectant Effect, International Journal of Preventive Medicine (2012)
7. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant Against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model, International Journal of Nephrology (2012)
8. N-Acetylcysteine and Cisplatin-Induced Nephrotoxicity: Is It a Suitable Antioxidant Supplementation to Prevent Nephrotoxicity in Male or Female Rats?, Journal of Isfahan Medical School (2013)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (56)
Ardeshir Talebi (41)
Other Related Docs
9. Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female, Nephro-Urology Monthly (2013)
10. Effect of Pomegranate Flower Extract on Cisplatin-Induced Nephrotoxicity in Rats, Journal of Nephropathology (2014)
11. The Effect of Testosterone and Estradiol on Renal Function Markers in Two Protocols of Cisplatin Induced Nephrotoxicity Models in Surgically Orchiectomized and Ovariectomized Rats, International Journal of Cancer Management (2019)
12. Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats, Asian Journal of Sports Medicine (2015)
13. Hydration With Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration During Cisplatin Therapy in Rat Models, Journal of Toxicology (2021)
14. The Reno-Protective Role of Angiotensin 1-7 in Cisplatin Induced Nephrotoxicity, Kuwait Medical Journal (2020)
15. Gender Difference in the Serum Levels of Total Nitric Oxide Metabolites, Nitrite, and Nitrate in Cisplatin-Induced Nephrotoxicity in Rats, Journal of Isfahan Medical School (2013)
16. Some Evidence for Sex-Based Differences in Cisplatininduced Nephrotoxicity in Rats, Clinical and Experimental Medical Letters (2012)
17. Nonpreventive Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Female Rats, International Journal of Preventive Medicine (2015)
18. Evaluation of the Protective Effect of Cystone Against Cisplatin-Induced Nephrotoxicity in Patients With Cancer: A Pilot Study, International Journal of Preventive Medicine (2019)
19. The Evaluation of L-Arginine Prophylaxis and Treatment on Preventing Nephrotoxicity Cisplatin-Induced in Rat: Role of Gender Difference, Journal of Isfahan Medical School (2015)
20. Effect of Testosterone on Cisplatin-Induced Nephrotoxicity in Surgically Castrated Rats, Nephro-Urology Monthly (2014)
21. Dextrose Hydration May Promote Cisplatin-Induced Nephrotoxicity in Rats: Gender-Related Difference, Indonesian Biomedical Journal (2019)
22. Nitric Oxide Metabolites Change in Cisplatin-Induced Nephrotoxicity: The Effect of L-Arginine and Losartan, Journal of Analytical Oncology (2013)
23. Sex Differences in Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-Induced Nephrotoxicity in Rats, Iranian Journal of Kidney Diseases (2013)
24. Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences, Asian Pacific Journal of Cancer Prevention (2017)
25. Evidence Against Protective Role of Sex Hormone Estrogen in Cisplatin-Induced Nephrotoxicity in Ovarectomized Rat Model, Toxicology International (2013)
26. Effects of Aqueous-Ethanolic Extract of Nigella Sativa Seeds (Black Cumin) and Vitamin E on Cisplatin-Induced Nephrotoxicity in Rat, Research Journal of Medicinal Plant (2016)
27. Mechanistic Impact of Medicinal Plants Affecting Cisplatin-Induced Nephrotoxicity; an Overview, Immunopathologia Persa (2019)
28. The Effect of Hydration Therapy With and Without Magnesium Sulfate on Prevention of Cisplatin-Induced Nephrotoxicity, Iranian Journal of Blood and Cancer (2019)
29. Nonprotective Role of Losartan in Cisplatin-Induced Nephrotoxicity in Ovariectomized Rat Model Treated With Estradiol, Journal of Pharmaceutical Negative Results (2015)
30. Cardiovascular Baroreflex Sensitivity Attenuates by Cisplatin-Induced Toxicity in Rats, Physiology and Pharmacology (2015)
31. Intravenous Administration of Cisplatin With Magnesium Sulfate Supplement May Prevent Kidney Toxicity in Rats: The Role of Gender and Magnesium Sulfate Dose, International Journal of Nephrology (2022)
32. Angiotensin 1-7 and Losartan Worsen the Cisplatin Induced Nephrotoxicity in Female Rats, Journal of Nephropharmacology (2022)
33. Does Vitamin E Mitigate Cisplatin-Induced Nephrotoxicity in Cancer Patients: Results From a Randomized Placebo-Controlled Clinical Trial, Middle East Journal of Cancer (2020)
34. Curcumin Supplementation Prevents Cisplatin-Induced Nephrotoxicity: A Randomized, Double-Blinded, and Placebo-Controlled Trial, Research in Pharmaceutical Sciences (2023)
35. The Protective Role of Endogenous Nitric Oxide Donor (L-Arginine) in Cisplatin-Induced Nephrotoxicity: Gender Related Differences in Rat Model, Journal of Research in Medical Sciences (2011)
36. The Prevention of Cisplatin-Induced Nephrotoxicity: A General Consensus Statement of a Group of Oncologist-Hematologists, Adult and Pediatric Nephrologists, Radiation Oncologists, Clinical Pathologists, Clinical Pharmacologists, and Renal Physiologists on Cisplatin Therapy in Cancer Patients, International Journal of Preventive Medicine (2022)
37. Comment On: A Model for Prediction of Cisplatin Induced Nephrotoxicity by Kidney Weight in Experimental Rats, Journal of Research in Medical Sciences (2013)
38. Effect of Short Hydration on Cisplatin-Induced Nephrotoxicity in Cancer Patients: A Retrospective Study, International Journal of Hematology-Oncology and Stem Cell Research (2017)
39. A Combination of Vitamin C and Losartan for Cisplatininduced Nephrotoxicity in Rats, Iranian Journal of Kidney Diseases (2012)
40. A Histopathological Study of Nephrotoxicity, Hepatoxicity or Testicular Toxicity: Which One Is the First Observation As Side Effect of Cisplatin-Induced Toxicity in Animal Model?, Journal of Nephropathology (2012)
41. Effect of Oral Administration of Magnesium on Cisplatin-Induced Nephrotoxicity in Normal and Streptozocin-Induced Diabetic Rats, Nephro-Urology Monthly (2013)
42. Pomegranate Flower Extract Does Not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats, International Journal of Preventive Medicine (2014)
43. Has Vitamin E Any Shreds of Evidence in Cisplatin-Induced Toxicity, Journal of Biochemical and Molecular Toxicology (2019)
44. Effects of Fennel Essential Oil on Cisplatin-Induced Nephrotoxicity in Ovariectomized Rats, Toxicology International (2013)
45. The Effects of Vitamin E and Selenium on Cisplatininduced Nephrotoxicity in Cancer Patients Treated With Cisplatin-Based Chemotherapy: A Randomized, Placebo-Controlled Study, Journal of Research in Medical Sciences (2012)
46. Melatonin in the Prevention of Cisplatin-Induced Acute Nephrotoxicity: A Randomized, Controlled Clinical Trial, Research in Pharmaceutical Sciences (2022)
47. Aerobic Exercise and Unripe Grape Extract As Antioxidant Do Not Protect the Kidney Against Cisplatin Induced Nephrotoxicity, Journal of Nephropathology (2019)
48. Effect of Aqueous Extract of Rheum Ribes on Cisplatin-Induced Nephrotoxicity in Rat, Journal of Pharmacy and Bioallied Sciences (2013)
49. Protective Effects of the Morus Alba L. Leaf Extracts on Cisplatininduced Nephrotoxicity in Rat, Research in Pharmaceutical Sciences (2013)
50. Elecampane Rhizome Extract Alleviates Methotrexate-Induced Hepatotoxicity and Nephrotoxicity in Male Rats, Advances in Traditional Medicine (2023)