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Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female Publisher



Nematbakhsh M1, 2, 3 ; Ebrahimian S1 ; Tooyserkani M1 ; Eshraghijazi F1 ; Talebi A1, 4 ; Ashrafi F1, 5
Authors
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Authors Affiliations
  1. 1. Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Nephro-Urology Monthly Published:2013


Abstract

Background: Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. Objectives: We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. Materials and Methods: Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), nitric oxide (NO) metabolite, and magnesium (Mg) levels were determined. Results: The percentage of weight loss and the serum levels of MDA and nitrite in male and female animals were not statistically different. However, the serum levels of BUN, Cr, Mg, and kidney MDA levels, and kidney weight and damage score were significantly greater in males than in females (P < 0.05). Conclusions: CP-induced nephrotoxicity is gender related for which the mechanisms should be determined. © 2013, Nephrology and Urology Research Center; Published by Kowsar Corp.
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