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Biodistribution and Toxicity Assessment of Radiolabeled and Dmsa Coated Ferrite Nanoparticles in Mice Publisher



Fatahian S1 ; Shahbazigahrouei D2 ; Pouladian M1 ; Yousefi MH3 ; Amiri GR4 ; Noori A4
Authors
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Authors Affiliations
  1. 1. Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Sciences, Nano-Center, Malek-Ashtar University of Technology Shahin-Shahr, Isfahan, P.O. Box 83145/115, Iran
  4. 4. Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2012


Abstract

DMSA-coated Fe3O4 nanoparticles were synthesized by wet-chemical method. The chemical interaction between Fe3O 4 and DMSA were investigated by FTIR. They were directly radiolabeled with 99mTc radioisotope (Fe3O4@DMSA- 99mTc) at room temperature in the presence of stannous solution as a reducing agent. Magnetic and structure properties of Fe3O 4@DMSA-99mTc nanoparticles were investigated by AGFM, TEM, and XRD. Biodistribution and toxicity assessment of Fe3O 4@DMSA-99mTc were studied in mice by intravenous and intraperitoneally injections, respectively. Blood, kidney, and liver factors were measured 4 days post injection and at the mean-while tissue sections were prepared from their kidney and liver. The results indicate that, the Fe 3O4@DMSA-99mTc nanoparticles were passed through the membrane of different cells but do not create any disorder in the kidney and liver function even in high doses such as 300 mg/kg. © 2012 Akademiai Kiado, Budapest, Hungary.
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