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Preparation and Magnetic Properties Investigation of Fe3o4 Nanoparticles Labaled With 99Mtc Radioisotope and Fe3o4 Nanoparticles Dmsa Coated



Fatahian S1 ; Shahbazi D2 ; Pouladian M1 ; Yousefi MH3 ; Amiri GHR4 ; Shahi Z2 ; Shahabadi M5 ; Jahanbakhsh H3
Authors
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Authors Affiliations
  1. 1. Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Medical Physics, Isfahan Medical University, Isfahan, Iran
  3. 3. Department of Sciences, Nano-Center, Malek-Ashtar University of Technology, Shahin-Shahr, Isfahan, P.O. Box 83145/115, Iran
  4. 4. Islamic Azad University, Falavarjan Branch, Isfahan, Iran
  5. 5. School of Electrical and Computer Engineering, University of Tehran, Iran

Source: Digest Journal of Nanomaterials and Biostructures Published:2011

Abstract

DMSA-coated Fe3O4 nanostructure was prepared by adding 1:2:8 proportions of FeCl2, FeCl3 and NaOH to deionized water, separately, under atmosphere control condition (N2). 0.01 M DMSA (C4S2O4H6) solution was prepared in deoxygenated deionized water. The solutions were added separately together slowly in a three spout balloon. Fe3O4 nanoparticles (5-20nm) were produced by co-precipitation method. Prepared Fe3O4 nanoparticles were labeled by 99mTc radioisotope directly at room temperature at the presence of SnCl2 as a reducing agent that reduces surface charge of the 99mTc. The labeling efficiency was assessed by instant thin layer chromatography (ITLC) and was found above 99 percent. Magnetic and structure properties of DMSA-coated and 99mTc labeled nanoparticles were investigated by Alternating Gradient-Force Magnetometer (AGFM), X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). Both of DMSA-coated Fe3O4 and 99mTc labeled Fe3O4 were super paramagnetic and their saturation magnetizations were determined 31 and 28 emu/g, respectively.
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