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Long Noncoding Rna-Mirna-Mrna Axes Multiple Roles in Osteosarcoma Publisher



Malakoti F1, 2 ; Alemi F1 ; Karimzadeh H3 ; Asemi Z4 ; Asadi M5 ; Ghobadi H1 ; Soleimanpour J6 ; Yousefi B1
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Clinical Biochemistry, School of Pharmacy & Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Gene Reports Published:2021


Abstract

Osteosarcoma is the most predominant primary bone malignant tumor in adolescents, characterized by high tumor mortality and poor treatment ratio. Long noncoding RNAs (lncRNAs) have important roles in key cell biological events encompassing differentiation, proliferation, development, invasion, and migration which accomplish this task by regulating genome functions including transcription, splicing, and epigenetics. Besides, some lncRNAs have been recently connected with the emergence of malignancy, and also important events involved in the cancer treatment process, such as drug sensitivity and resistance. In this article, we reviewed the effects of lncRNAs on osteosarcoma cells progression, prognosis, and drug resistance by modulating miRNAs and signaling pathways. © 2021 Elsevier Inc.
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