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Multiple Function of Lncrna Malat1 in Cancer Occurrence and Progression Publisher Pubmed



Malakoti F1, 2 ; Targhazeh N1 ; Karimzadeh H3 ; Mohammadi E4, 5 ; Asadi M5 ; Asemi Z6 ; Alemi F1
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student's Research committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Clinical Biochemistry, School of Pharmacy & Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
  5. 5. Department of Basic Oncology, Health Institute of Ege University, Izmir, Turkey
  6. 6. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Source: Chemical Biology and Drug Design Published:2023


Abstract

Long non-coding RNAs (lncRNAs) have received particular attention in the last decade due to its engaging in carcinogenesis and tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a lncRNA that plays physiological and pathological roles in many aspects of genome function as well as biological processes involved in cell development, differentiation, proliferation, invasion, and migration. In this article, we will review the effects of lncRNA MALAT1 on the progression of six prevalent human cancers by focusing on MALAT1 ability to regulate post-transcriptional modification and signaling pathways. © 2021 John Wiley & Sons A/S.
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