Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Dietary Intake of Fatty Acids and Colorectal Cancer, a Case-Control Study Publisher



Shekari S1 ; Fathi S2 ; Roumi Z3 ; Akbari ME4 ; Tajadod S5 ; Afsharfar M6 ; Hasanpour Ardekanizadeh N7 ; Bourbour F8 ; Keshavarz SA9 ; Sotoudeh M1 ; Gholamalizadeh M4 ; Nemat Gorgani S10 ; Shafaei Kachaei H11 ; Alizadeh A12 Show All Authors
Authors
  1. Shekari S1
  2. Fathi S2
  3. Roumi Z3
  4. Akbari ME4
  5. Tajadod S5
  6. Afsharfar M6
  7. Hasanpour Ardekanizadeh N7
  8. Bourbour F8
  9. Keshavarz SA9
  10. Sotoudeh M1
  11. Gholamalizadeh M4
  12. Nemat Gorgani S10
  13. Shafaei Kachaei H11
  14. Alizadeh A12
  15. Doaei S13
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, International Campus, Tehran, Iran
  6. 6. Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  7. 7. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Clinical Nutrition and Dietetics, Research Institute, Shahid Beheshti University of Medical Science, Tehran, Iran
  11. 11. School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
  13. 13. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Nutrition Published:2022


Abstract

Background: The association of dietary fat and colorectal cancer (CRC) was frequently reported. However, few studies assessed the effects of different types of dietary fats on CRC. This study aimed to investigate the association between intakes of different types of dietary fatty acids with colorectal cancer risk. Methods: This case-control study was conducted on 480 participants including 160 CRC cases and 320 healthy controls in Firoozgar Hospital, Tehran, Iran. The intake of dietary fatty acids of the participants was assessed using a semi quantitative food frequency questionnaire (FFQ). Results: The mean intake of cholesterol (273.07 ± 53.63 vs. 254.17 ± 61.12, P = 0.001), polyunsaturated fatty acids (PUFA) (16.54 ± 4.20 vs. 15.41 ± 4.44, P = 0.012), and calorie (2,568.76 ± 404.48 vs. 2,493.38 ± 176.03, P = 0.006) was higher and the mean intake of oleic acid (5.59 ± 3.17 vs. 8.21 ± 5.46) and linoleic acid (6.03 ± 3.44 vs. 7.02 ± 4.08, P = 0.01) was lower in the case group compared to the control group. An inverse association was found between colorectal cancer (CRC) and dietary intake of oleic acid (OR: 0.85, CI 95% 0.80–0.90, P = 0.001), linoleic acid (OR: 0.85, CI 95% 0.78–0.93, P = 0.001), and α-linolenic acid (OR: 0.75, CI 95% 0.57–0.98, P = 0.04). The association remained significant after adjusting for age and sex, sleep, smoking, and alcohol consumption, and BMI. Conclusions: The results of this study support a protective effect of oleic acid, linoleic acid, and α-linolenic acid against CRC. Further longitudinal studies are warranted to confirm these results. Copyright © 2022 Shekari, Fathi, Roumi, Akbari, Tajadod, Afsharfar, Hasanpour Ardekanizadeh, Bourbour, Keshavarz, Sotoudeh, Gholamalizadeh, Nemat Gorgani, Shafaei Kachaei, Alizadeh and Doaei.
Related Docs
View other Related Docs
1. Associations of Dietary Fat Types (Mufa, Pufa, Sfa) and Sources (Animal, Plant) With Colorectal Cancer Risk: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Cancer Epidemiology (2025)
2. The Association Between Different Types of Dietary Carbohydrates and Colorectal Cancer: A Case-Control Study, Frontiers in Nutrition (2022)
3. The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake, Frontiers in Nutrition (2023)
4. Association Between Major Dietary Patterns and Risk of Colon Cancer, Journal of Isfahan Medical School (2011)
5. The Association Between Dietary Quality Indices and Colorectal Cancer Risk: A Case-Control Study, International Journal of Nutrition Sciences (2024)
6. Association of Different Types of Dietary Fatty Acids With Breast Cancer, a Case-Control Study, Nutrition and Food Science (2022)
7. Dietary and Lifestyle Indices for Hyperinsulinemia and Colorectal Cancer Risk: A Case-Control Study, BMC Gastroenterology (2023)
8. Dietary Intakes of Monounsaturated Fatty Acids and Risk of Mortality From All Causes, Cardiovascular Disease and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Ageing Research Reviews (2021)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (43)
Noushin Mohammadifard (40)
Other Related Docs
9. Association Between Adherence to a Dietary Approach to Stop Hypertension and the Mediterranean Diets and Risk of Colorectal Cancer: A Matched Case-Control Study, Clinical Nutrition ESPEN (2024)
10. Carbohydrate Quality Indices and Colorectal Cancer Risk: A Case-Control Study, BMC Cancer (2023)
11. The Association Between Dietary Diversity Score and Risk of Prostate Cancer: (A Case-Control Study), Nutrition and Cancer (2022)
12. The Association Between Different Kinds of Fat Intake and Breast Cancer Risk in Women, International Journal of Preventive Medicine (2014)
13. The Association Between Pro-Vegetarian Dietary Pattern and Risk of Colorectal Cancer: A Matched Case-Control Study, BMC Research Notes (2023)
14. Oxidative Balance Score and Dietary Phytochemical Index Can Reduce the Risk of Colorectal Cancer in Iranian Population, BMC Gastroenterology (2023)
15. Relation Between Food Intake, Food Insecurity, and Body Composition in Patients With Colorectal Cancer, Journal of Health System Research (2020)
16. Dietary Total Antioxidant Capacity and Risk of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis of Observational Studies, Archives of Iranian Medicine (2019)
17. Multiple Associations of Clinicopathological Characteristics and Risk Factors of Colorectal Cancer in the Iranian Population, Middle East Journal of Cancer (2021)
18. Erythrocyte Membrane Saturated Fatty Acids Profile in Newly Diagnosed Basal Cell Carcinoma Patients, Clinical Nutrition ESPEN (2018)
19. Dietary Intake and Serum Levels of Trans Fatty Acids and Risk of Breast Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies, Clinical Nutrition (2020)
20. Ultra-Processed Food Intake and Risk of Colorectal Cancer: A Matched Case-Control Study, Nutrition and Cancer (2023)
21. A Healthful Plant-Based Diet Can Reduce the Risk of Developing Colorectal Cancer: Case-Control Study, Journal of Health, Population and Nutrition (2024)
22. Dietary Linoleic Acid Intake in Relation to Breast Cancer: A Case-Control Study, Health Promotion Perspectives (2023)
23. Patterns of Nutrient Intake in Relation to Gastric Cancer: A Case Control Study, Nutrition and Cancer (2022)
24. The Association Between Dietary Total Antioxidant Capacity With Risk of Rheumatoid Arthritis in Adults: A Case–Control Study, Clinical Nutrition ESPEN (2022)
25. Global, Regional, and National Burden of Colorectal Cancer and Its Risk Factors, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019, The Lancet Gastroenterology and Hepatology (2022)
26. Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women With Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial, International journal of clinical practice (2022)
27. Dietary Intake and Biomarkers of Linoleic Acid and Risk of Prostate Cancer in Men: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2024)
28. Inflammatory Potential of Diet and Odds of Lung Cancer: A Case-Control Study, Nutrition and Cancer (2022)
29. Association of Dietary Fats With Ischemic Heart Disease (Ihd): A Case–Control Study, Journal of Health, Population and Nutrition (2024)
30. Adherence to the Low Carbohydrate Diet and the Risk of Breast Cancer in Iran, Nutrition Journal (2019)
31. Fruit and Vegetable Intake in Relation to Gastric Cancer Risk: A Comprehensive and Updated Systematic Review and Dose-Response Meta-Analysis of Cohort Studies, Frontiers in Nutrition (2023)
32. The Relationship Between Breast Cancer Prognosis and Dietary Patterns in Women With Breast Cancer in Jahrom City, Iranian Journal of Obstetrics, Gynecology and Infertility (2023)
33. Dietary Intake and Biomarkers of Alpha Linolenic Acid and Risk of All Cause, Cardiovascular, and Cancer Mortality: Systematic Review and Dose-Response Meta-Analysis of Cohort Studies, The BMJ (2021)
34. Validity and Reproducibility of a Semi-Quantitative Food Frequency Questionnaire for Iranian Adults, Nutrition and Dietetics (2021)
35. Legume and Nuts Consumption in Relation to Odds of Breast Cancer: A Case-Control Study, Nutrition and Cancer (2021)
36. A Case–Control Study on the Association Between Adherence to a Mediterranean-Style Diet and Breast Cancer, Frontiers in Nutrition (2023)
37. Association Between the Dietary Inflammatory Index and the Incidence of Cancer: A Systematic Review and Meta-Analysis of Prospective Studies, Public Health (2018)
38. Study of Saturated Fatty Acids in Different Traditional Foods Distributed in Isfahan, Iran, Journal of Health System Research (2020)
39. Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematireview and Dose-Response Meta-Analysis of Prospective Cohort Studies, Diabetes Care (2021)
40. Association Between Type 2 Diabetes and Different Types of Dietary Fats: A Case-Control Study, Clinical Nutrition ESPEN (2023)
41. Comparison of Validity of the Food Frequency Questionnaire and the Diet History Questionnaire for Assessment of Energy and Nutrients Intakes in an Iranian Population; [Comparaison De La Validite Du Questionnaire De Frequence Alimentaire Et Du Questionnaire Sur Les Habitudes Alimentaires Dans L’Evaluation Des Apports En Energie Et En Nutriments Dans Une Population Iranienne], Eastern Mediterranean Health Journal (2020)
42. A Case-Control Study of Dietary Approaches to Stop Hypertension (Dash) Diets, Colorectal Cancer and Adenomas Among Iranian Population, BMC Cancer (2021)
43. The Effect of Fto Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Fiber, Frontiers in Nutrition (2022)
44. Which Diets Are Effective in Reducing Cardiovascular and Cancer Risk in Women With Obesity? an Integrative Review, Nutrients (2021)
45. A Comparison of Fatty Acid Profiles in Highly Demanded Traditional and Fast Foods in Isfahan, Iran, Journal of Nutrition and Food Security (2022)
46. Consumption of “Diabetes Risk Reduction Diet” and Odds of Breast Cancer Among Women in a Middle Eastern Country, Frontiers in Nutrition (2022)
47. Dietary Patterns and Risk of Breast Cancer Among Pre and Post-Menopausal Women: A Case-Control Study in Iran, Journal of Nutrition and Food Security (2022)
48. Adherence to Dietary Approaches to Stop Hypertension (Dash)-Style Diet and the Risk of Cancer: A Systematic Review and Meta-Analysis of Cohort Studies, Journal of the American College of Nutrition (2019)
49. Assessment of the Distribution of Usual Intake of Nutrients and Estimating Prevalence of Intake Deficiency and Excess in a General Over 40-Years of Age Population of Central Region of Iran: Application of the National Cancer Institute (Nci) Method, Journal of Isfahan Medical School (2013)
50. Adherence to Low-Carbohydrate Diet in Relation to Gastric Cancer: Findings From a Case-Control Study in Iran, European Journal of Cancer Prevention (2021)