Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Immunologic and Psychologic Parameters Associated With Geographic Tongue Publisher Pubmed



Alikhani M1 ; Khalighinejad N2 ; Ghalaiani P2 ; Khaleghi MA2 ; Askari E3 ; Gorsky M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Torabinejad Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Psychology Department, Allameh University, Tehran, Iran
  4. 4. Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Published:2014


Abstract

Objective Several conditions have been associated with geographic tongue (GT). However, there is no consensus on the etiology of GT. The purpose of this study was to investigate whether immunologic and psychologic parameters are associated with diagnosis of GT. Study Design A case-control study was performed on 170 participants (85 with GT, 85 controls). Unstimulated whole saliva was collected, and tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) concentrations were measured. Anxiety level was measured using psychologic and physiologic testing instruments. An independent t test and a Pearson correlation analysis were performed with SPSS (α =.05). Results There was a significant difference between the 2 groups regarding the salivary concentrations of TNF-α (P =.008) and IL-6 (P =.001). The concentration of salivary cortisol and state and trait anxiety levels in the GT group were significantly higher than those in the control group (P =.001). Conclusions Immunologic and psychologic parameters appear associated with GT and may constitute risk factors of this condition. © 2014 Elsevier Inc. All rights reserved.
Other Related Docs
9. Salivary Concentration of Tnfα, Il1α, Il6, and Il8 in Oral Squamous Cell Carcinoma, Medicina Oral, Patologia Oral y Cirugia Bucal (2008)