Immunomodulatory Effects of Flavonoids: Possible Induction of T Cd4+ Regulatory Cells Through Suppression of Mtor Pathway Signaling Activity Publisher Pubmed



Hosseinzade A¹ ; Sadeghi O^{2, 3} ; Biregani AN⁴ ; Soukhtehzari S⁵ ; Brandt GS⁶ ; Esmaillzadeh A^{2, 7, 8} Show Affiliations
Source: Frontiers in Immunology Published:2019

Abstract

The increasing rate of autoimmune disorders and cancer in recent years has been a controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among dietary factors, flavonoids have specific immunomodulatory effects that might be of importance to several cancers. Over different types of immune cells, T lymphocytes play a critical role in protecting the immune system as well as in the pathogenesis of specific autoimmune diseases. One of the important mediators of metabolism and immune system is mTOR, especially in T lymphocytes. In the current review, we assessed the effects of flavonoids on the immune system and then their impact on the mTOR pathway. Flavonoids can suppress mTOR activity and are consequently able to induce the T regulatory subset. © 2019 Hosseinzade, Sadeghi, Naghdipour Biregani, Soukhtehzari, Brandt and Esmaillzadeh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.