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Quercetin Modulates Signal Transductions and Targets Non-Coding Rnas Against Cancer Development Publisher Pubmed



Homayoonfal M1 ; Gilasi H2 ; Asemi Z1 ; Khaksary Mahabady M3 ; Asemi R4 ; Yousefi B5, 6
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Biostatistics and Epidemiology, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Cellular Signalling Published:2023


Abstract

In recent decades, various investigations have indicated that natural compounds have great potential in the prevention and treatment of different chronic disorders including different types of cancer. As a bioactive flavonoid, Quercetin (Qu) is a dietary ingredient enjoying high pharmacological values and health-promoting effects due to its antioxidant and anti-inflammatory characterization. Conclusive in vitro and in vivo evidence has revealed that Qu has great potential in cancer prevention and development. Qu exerts its anticancer influences by altering various cellular processes such as apoptosis, autophagy, angiogenesis, metastasis, cell cycle, and proliferation. In this way, Qu by targeting numerous signaling pathways as well as non-coding RNAs regulates several cellular mechanisms to suppress cancer occurrence and promotion. This review aimed to summarize the impact of Qu on the molecular pathways and non-coding RNAs in modulating various cancer-associated cellular mechanisms. © 2023 Elsevier Inc.
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