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Possible Involvement of the Dopamine D2 Receptors of Ventromedial Hypothalamus in the Control of Free- and Scheduled-Feeding and Plasma Ghrelin Level in Rat Publisher Pubmed



Mehranfard N1 ; Halabian A2 ; Alaei H3 ; Radahmadi M3 ; Bahari Z4 ; Ghasemi M3
Authors
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Authors Affiliations
  1. 1. Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran
  2. 2. Department of Biology, School of Science, Isfahan University, Isfahan, Iran
  3. 3. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Journal of Complementary and Integrative Medicine Published:2021


Abstract

Objectives: We investigated effect of the ventromedial hypothalamus (VMH) dopamine D2 receptor inhibition on food intake and plasma ghrelin following chronic free or scheduled meal with different caloric intakes. Methods: Male Wistar rats (220-250 g) were fed diets containing free (control) or three scheduled diets of standard, restricted and high-fat for 1 month. The animals stereotaxically received an intra VMH single dose of sulpiride (0.005 μg)/or saline (0.5 μL) before meal time. Thirty minutes later, food intake and circulating ghrelin were measured. Results: Sulpiride significantly reduced food intake and ghrelin concentration in freely fed and scheduled-standard diet (p<0.05), while increased food intake, with ghrelin level on fasted level in scheduled-restricted group (p<0.01) compared to control. Food intake and ghrelin concentration between scheduled-high fat and freely fed or scheduled-standard diets did not show significant changes. Conclusions: The VMH D2 receptors are possibly involved in controlling scheduled eating behavior, depending on energy balance context. © 2021 Walter de Gruyter GmbH, Berlin/Boston.
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