Microencapsulation of Budesonide With Dextran by Spray Drying Technique for Colon-Targeted Delivery: An in Vitro/In Vivo Evaluation in Induced Colitis in Rat Publisher Pubmed



Varshosaz J¹ ; Ahmadi F¹ ; Emami J¹ ; Tavakoli N¹ ; Minaiyan M² ; Mahzouni P³ ; Dorkoosh F⁴
Source: Journal of Microencapsulation Published:2011

Abstract

The aim of this study was developing colon targeted-delivery of budesonide for ulcerative colitis. Microcapsules were prepared using spray drying technique by different drug-to-dextran ratios and three molecular weights (MWs) of polymer. Differential scanning calorimetry, X-ray diffraction (XRD), drug release and loading efficiency of microcapsules were studied. In vivo efficacy of the selected formulation prepared by 1:10 drug-to-polymer ratio and dextran with MW 500000 (D10M500) against acetic acid-induced colitis in rats was evaluated and compared to the control and reference groups (mesalasine and budesonide suspensions). The results showed that D10M500 microcapsules could target the drug to colon and its efficacy in reducing macroscopic damage score was higher than mesalasine suspension. Treatment with D10M500 decreased the scores of crypt damage and total colitis significantly compared to the control group which just received the vehicle and the groups treated with mesalasine and budesonide suspension which could not reduce the colitis parameters significantly. © 2011 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.