Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
One Year Follow-Up Effect of Renal Sympathetic Denervation in Patients With Resistant Hypertension



Pourmoghaddas M1 ; Khosravi A2 ; Akhbari M3 ; Akbari M4 ; Purbehi M3 ; Ziaei F2 ; Salehizade L2 ; Sistan N5 ; Esmaeili M5 ; Bidram P6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2016

Abstract

Background: Resistant hypertension is a common clinical problem of blood pressure that is not controlled despite the simultaneous application of multiple antihypertensive agents. Ablation of renal afferent nerves has been applied and proved to decrease hypertension and injuries produced by severe sympathetic hyperactivity. The main objective of this study was to investigate the long-term effect of renal artery sympathetic ablation and its complications in patients with treatment-resistant hypertension. Methods: In this prospective study which done between March 2012 and November 2013, 30 patients with resistant arterial hypertension despite treatment with ≥3 antihypertensive drugs-were randomly enrolled in this self-control clinical study in Isfahan, Iran. The patients were treated with the renal denervation procedure; the femoral artery was accessed with the standard endovascular technique and the Symplicity catheter was advanced into the renal artery and connected to a radiofrequency generator. Before and 12 months after renal denervation procedure waist, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), metabolic syndrome, fasting blood sugar (FBS), high-density lipoprotein (HDL), and triglyceride were measured in all patients. Results: Both mean SBP and DBP were significantly decreased, 12 months after renal denervation (P < 0.001). The frequency of metabolic syndrome was not significantly different after renal denervation in compare to baseline (P = 0.174). Furthermore, a significant decreased in FBS and triglyceride was observed in compare to baseline (P = 0.001). Conclusion: This study highlighted the role of renal sympathetic denervation as a modern and secure catheter-based method for sustained reduction hypertension in treatment-resistant cases. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Role of Mas Receptor on Renal Hemodynamic Responses to Angiotensin Ii Administration in Chronic Renal Sympathectomized Male and Female Rats, Research in Pharmaceutical Sciences (2023)
2. The Denervation or Activation of Renal Sympathetic Nerve and Renal Blood Flow, Journal of Research in Medical Sciences (2023)
3. Cost-Effectiveness of Interventional Therapies for Management of Treatment-Resistant Hypertension: Systematic Review of Pharmacoeconomic Studies, Journal of Pharmaceutical Health Services Research (2020)
4. The Effect of At2 and Mas Receptors Antagonists on Renal Hemodynamic and Excretory Disorders Induced by Ischemia/Reperfusion in Male and Female Rats, Physiology and Pharmacology (Iran) (2018)
5. Evaluation of Blood Pressure Changes Using Ambulatory Blood Pressure Monitoring (Abpm) in Children Undergoing Kidney Transplantation and Its Relationship With Left Ventricular Mass Index, and Level of Serum Angiotensin and Atrial Natriuretic Peptide, Journal of Isfahan Medical School (2012)
6. Role of Mas Receptor Antagonist (A779) on Pressure Diuresis and Natriuresis and Renal Blood Flow in the Absence of Angiotensin Ii Receptors Type 1 and 2 in Female and Male Rats, Journal of Physiology and Pharmacology (2014)
7. Renal Vascular Responses to Angiotensin Ii Infusion in Two Kidneys-One Clip Hypertensive Rats Under Partial Ischemia/Reperfusion With and Without Ischemia Preconditioning: The Roles of At1r Blockade and Co-Blockades of At1r and Masr, Research in Pharmaceutical Sciences (2023)
8. Effect of Sitagliptin on Proteinuria in Patients With Type 2 Diabetes-A Renoprotective Effect of Sitagliptin, Journal of Research in Medical Sciences (2021)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (13)
Ali Asghar Pourshanazari (4)
Other Related Docs
9. Possible Correlation Among Echocardiographic Measures, Serum Brain Natriuretic Peptide, and Angiotensin Ii Levels in Hypertensive Kidney Transplanted Children, Experimental and Clinical Transplantation (2013)
10. Gender Difference in Renal Blood Flow Response to Angiotensin Ii Administration After Ischemia/Reperfusion in Rats: The Role of At2 Receptor, Advances in Pharmacological Sciences (2016)
11. Mas Receptor Antagonist (A799) Alters the Renal Hemodynamics Responses to Angiotensin Ii Administration After Renal Moderate Ischemia/Reperfusion in Rats: Gender Related Differences, Research in Pharmaceutical Sciences (2019)
12. Renal Denervation Effects on Blood Pressure in Resistant and Uncontrolled Hypertension: A Meta-Analysis of Sham-Controlled Randomized Clinical Trials, Clinical Cardiology (2025)
13. Cotimparave Evaluation of Oral Alprazolam, As Premedication, on Controlling Blood Pressure in Hypertensive Patients During Surgery, Journal of Isfahan Medical School (2015)
14. Angiotensin 1-7 Administration Alters Baroreflex Sensitivity and Renal Function in Sympathectomized Rats, Journal of Nephropathology (2018)
15. Mas Receptor Blockade Promotes Renal Vascular Response to Ang Ii After Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One-Clip Hypertensive Rats Model, International Journal of Nephrology (2021)
16. Antihypertensive Drug Prescription Trends in Shahrekord, Iran, Journal of Nephropharmacology (2022)
17. Is Using Antihypertensive Drugs Before Arteriovenous Fistula Surgery Effective on Fistula Thrombosis in Patients With Hypertension?, Journal of Isfahan Medical School (2017)
18. Epidemiologic Evaluation of Demographic and Basic Clinical Factors in Patients With Chronic Kidney Disease in Isfahan City, Iran, During 1996-2011, Journal of Isfahan Medical School (2017)
19. The Outcomes of Percutaneous Transluminal Renal Artery Angioplasty in Hypertensive Patients: An Interventional Study, Journal of Isfahan Medical School (2010)
20. The Role of the At1 Receptor Antagonist on Renal Hemodynamic Responses to Angiotensin 1-7 in Acute Sympathectomized Male and Female Rats, Physiology and Pharmacology (Iran) (2024)
21. The Effect of N-Acetylcysteine in Prime Solution on Preventing Renal Failure During Cardiopulmonary Bypass Surgery, Journal of Isfahan Medical School (2021)
22. Serum Uric Acid and Salt Sensitivity in the Normotensive Population: An Iranian Sample, Iranian Heart Journal (2018)
23. Renal Denervation Influences Angiotensin Ii Types 1 and 2 Receptors, International Journal of Nephrology (2022)
24. Hypertension and Chronic Kidney Disease; a Mutual Relationship, Journal of Renal Injury Prevention (2024)
25. Role of Mas Receptor Antagonist (A779) in Renal Hemodynamics in Condition of Blocked Angiotensin Ii Receptors in Rats, Acta Physiologica Hungarica (2016)
26. The Effects of Mas Receptor Antagonist (A779) and Renal Perfusion Pressure on Serum Nitrite Concentration in Male and Female Rats When Angiotensin Ii Receptors 1 & 2 Were Blocked, Physiology and Pharmacology (2015)