Hypertension and Chronic Kidney Disease; a Mutual Relationship Publisher



Golafshan F¹ ; Shafieyoon M¹ Show Affiliations
Source: Journal of Renal Injury Prevention Published:2024

Abstract

Hypertension (HTN) and chronic kidney disease (CKD) have a mutual relationship. HTN is both a risk factor for and a complication of CKD due to various mechanisms. High blood pressure causes damage to blood vessels, including those in the kidneys, contributing to reduced kidney function over time. Meanwhile, decreasing kidney function leads to salt and water retention, increased activity of the renin-angiotensin-aldosterone system, and other effects that worsen HTN. Tight blood pressure control through lifestyle modification and medication is essential for slowing CKD progression and lowering the risk of associated cardiovascular complications. Understanding the intersecting pathophysiology between HTN and CKD is critical for optimal management. This paper summarizes current evidence on this relationship and its implications for treatment considerations. Further research is warranted on interventions that can effectively disrupt the vicious cycle connecting HTN and progressive CKD. © 2024 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited