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The Efficacy of Ginseng Supplementation on Plasma Lipid Concentration in Adults: A Systematic Review and Meta-Analysis Publisher Pubmed



Ziaei R1 ; Ghavami A2 ; Ghaedi E3, 4 ; Hadi A5 ; Javadian P6 ; Clark CCT7
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, Food Security Research center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Halal Research Center of IRI, FDA, Tehran, Iran
  6. 6. Department of Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  7. 7. Faculty Research Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, United Kingdom

Source: Complementary Therapies in Medicine Published:2020


Abstract

Objective: We performed a meta-analysis to evaluate the efficacy of ginseng supplementation on plasma lipid concentration. Methods: The search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to April 2019) to identify randomized controlled trials (RCTs) investigating the effect of ginseng supplementation on serum lipid parameters. To estimate the overall summary effect, we used random-effects model. Results: Twenty-seven studies comprising 35 treatment arms comprising 1245 participants fulfilled the inclusion criteria. The meta-analysis results showed that consumption of ginseng did not significantly change the concentrations of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). However, subgroup analyses showed a significant lowering effect in high dose ginseng supplementation on TC, LDL-C and TG. Also, the impact of ginseng on TC and TG was significant in long-term interventions. Conclusion: Further RCTs with longer supplementation durations in subjects with dyslipidemia are necessitated for a more robust assessment of the lipid-modulating properties of this plant. © 2019 Elsevier Ltd
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