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The Effects of Guar Gum Supplementation on Lipid Profile in Adults: A Grade-Assessed Systematic Review, Meta-Regression and Dose-Response Meta-Analysis of Randomised Placebo-Controlled Trials Publisher Pubmed



Setayesh L1 ; Pourreza S2 ; Zeinali Khosroshahi M3 ; Asbaghi O4 ; Bagheri R5 ; Rezaei Kelishadi M6 ; Wong A7 ; Clark CCT8 ; Larky DA9 ; Suzuki K10 ; Ghanavati M11
Authors
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Authors Affiliations
  1. 1. Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States
  2. 2. Department of Clinical Nutrition, School of Nutritional Science, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Exercise Physiology, University of Isfahan, Isfahan, Iran
  6. 6. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Health and Human Performance, Marymount University, Arlington, United States
  8. 8. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, United Kingdom
  9. 9. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  10. 10. Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, 359-1192, Japan
  11. 11. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: British Journal of Nutrition Published:2023


Abstract

Recent meta-analytic work indicated that guar gum supplementation might improve lipid profile markers in different populations. However, critical methodological limitations such as the use of some unreliable data and the lack of inclusion of several relevant studies, and the scarcity in assessments of regression and dose-specific effects make it difficult to draw meaningful conclusions from the meta-analysis. Therefore, current evidence regarding the effects of guar gum supplementation on lipid profile remains unclear. The present systematic review, meta-regression and dose-response meta-analysis aimed to examine the effects of guar gum supplementation on lipid profile (total cholesterol (TC), LDL, TAG and HDL) in adults. Relevant studies were obtained by searching the PubMed, SCOPUS, Embase and Web of Science databases (from inception to September 2021). Weighted mean differences (WMD) and 95 % CI were estimated via a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods. Pooled analysis of nineteen randomised controlled trials (RCT) revealed that guar gum supplementation led to significant reductions in TC (WMD: -19·34 mg/dl, 95 % CI -26·18, -12·49, P < 0·001) and LDL (WMD: -16·19 mg/dl, 95 % CI -25·54, -6·83, P = 0·001). However, there was no effect on TAG and HDL among adults in comparison with control group. Our outcomes suggest that guar gum supplementation lowers TC and LDL in adults. Future large RCT on various populations are needed to show further beneficial effects of guar gum supplementation on lipid profile and establish guidelines for clinical practice. © University, 2022. Published by Cambridge University Press on behalf of The Nutrition Society.
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