Periodontitis and Progression of Gastrointestinal Cancer: Current Knowledge and Future Perspective Publisher Pubmed



Nasiri K¹ ; Amiri Moghaddam M² ; Etajuri EA³ ; Badkoobeh A⁴ ; Tavakol O⁵ ; Rafinejad M⁶ ; Forutan Mirhosseini A⁷ ; Fathi A⁸
Source: Clinical and Translational Oncology Published:2023

Abstract

Periodontitis is a polymicrobial disorder caused by dysbiosis. Porphyromonas gingivalis (P.gingivalis) and Fusobacterium nucleatum (F.nucleatum) are pathobiont related to periodontitis pathogenesis and were found to be abundant in the intestinal mucosa of inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. Besides, periodontal infections have been found in a variety of tissues and organs, indicating that periodontitis is not just an inflammation limited to the oral cavity. Considering the possible translocation of pathobiont from the oral cavity to the gastrointestinal (GI) tract, this study aimed to review the published articles in this field to provide a comprehensive view of the existing knowledge about the relationship between periodontitis and GI malignancies by focusing on the oral/gut axis. © 2023, The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO).