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Periodontitis and Progression of Gastrointestinal Cancer: Current Knowledge and Future Perspective Publisher Pubmed



Nasiri K1 ; Amiri Moghaddam M2 ; Etajuri EA3 ; Badkoobeh A4 ; Tavakol O5 ; Rafinejad M6 ; Forutan Mirhosseini A7 ; Fathi A8
Authors
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Authors Affiliations
  1. 1. Department of Dentistry, Islamic Azad University, Tehran, Iran
  2. 2. Department of Periodontics, Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  4. 4. Department of Oral and Maxillofacial Surgery, School of Dentistry, Qom University of Medical Sciences, Qom, Iran
  5. 5. Department of Prosthodontics, Islamic Azad University, Shiraz, Iran
  6. 6. Department of Dentistry, Borujerd University of Medical Science, Borujerd, Iran
  7. 7. Student Research Committee, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
  8. 8. Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Clinical and Translational Oncology Published:2023


Abstract

Periodontitis is a polymicrobial disorder caused by dysbiosis. Porphyromonas gingivalis (P.gingivalis) and Fusobacterium nucleatum (F.nucleatum) are pathobiont related to periodontitis pathogenesis and were found to be abundant in the intestinal mucosa of inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. Besides, periodontal infections have been found in a variety of tissues and organs, indicating that periodontitis is not just an inflammation limited to the oral cavity. Considering the possible translocation of pathobiont from the oral cavity to the gastrointestinal (GI) tract, this study aimed to review the published articles in this field to provide a comprehensive view of the existing knowledge about the relationship between periodontitis and GI malignancies by focusing on the oral/gut axis. © 2023, The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO).
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