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Exosomes Derived From Mesenchymal Stem Cells: Heralding a New Treatment for Periodontitis? Publisher Pubmed



Mousavi E1 ; Khosravi A2 ; Sedigh SS3 ; Mayanei SAT4 ; Banakar M5 ; Karimzadeh M6 ; Fathi A7
Authors
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Authors Affiliations
  1. 1. Dental Sciences Research Center, Department of Endodontics, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Department of Periodontics, Dental School, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran
  3. 3. Department of Periodontics, Rafsanjan School of Dentistry, Kerman, Iran
  4. 4. Dental Department, Dental College, Baku Medical University, Baku, Azerbaijan
  5. 5. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of dentistry, Islamic Azad University, Tehran Medical Sciences, Tehran, Iran
  7. 7. Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Tissue and Cell Published:2023


Abstract

Periodontitis, as a complex inflammatory disorder, is characterized by continuous destruction of the teeth-supporting components, like alveolar bone and periodontal ligament, and affects a great percentage of individuals over the world. Also, this oral disease is linked with multiple serious illnesses, e.g., cardiovascular disorders, diabetes, and oral cancer; thus, exerting efficient therapy for periodontitis is necessary. Unfortunately, the current therapies for the disease (e.g., surgical and nonsurgical methods) have not reflected enough effectiveness against periodontitis. At present, mesenchymal stem cell (MSC)-based remedy has created new hope for curating different diseases; however, MSCs have no capability to engraft into the chosen tissue, and the tumorigenic influences of MSCs are still the main concern. Interestingly, documents have revealed that MSC-derived mediators, like exosomes, which their exploitation is more feasible than intact MSCs, can be an effective therapeutic candidate for periodontitis. Therefore, in this study, we will review evidence in conjunction with their possible curative impacts on periodontitis cases. © 2023
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