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Mirna, Biogenesis and Mechanisms of Regulations



Ehtesham N1 ; Modi M1 ; Kheirollahi M1
Authors
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Authors Affiliations
  1. 1. Pediatric Inherited Diseases Research Center, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2014

Abstract

miRNAs (microRNAs) were discovered in 1993 in Caenorhabditis elegans as one of the most important gene expression regulatory factors. This regulatory role includes many of the important intracellular processes like genesis, differentiation, proliferation and apoptosis. miRNAs are among mRNAs and like them are transcribed by RNA polymerase II and then cap and polyA tail are added to them. The resulted pri-miRNA converts to mature miRNA by two sequential trimming reactions. miRNAs exerts their regulatory effects by translation repression, translation activation and mRNA degradation. miRNAs have an important role in regulation of immune and nervous systems and disorder in their expression can lead to separate disease in both systems. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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