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Scaffolds: A Biomaterial Engineering in Targeted Drug Delivery for Osteoporosis Publisher Pubmed



Poorirani S1 ; Taheri S1 ; Mostafavi SA1
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Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Hezar Jerib Street, Isfahan, 8174673461, Iran

Source: Osteoporosis International Published:2023


Abstract

Osteoporosis is an increasingly common condition that causes low bone density, porous bone, and increased fracture risk. Treatments for osteoporosis are divided into two categories: (a) antiresorptive and (b) anabolic. To decrease side effects of drug and dosage level variations caused by several consecutive administrations, various drug delivery systems have been proposed. Among them, scaffolds are one of the drug delivery systems that led to drug impart with high loading and suitable efficiency to specific sites which retain active agents at acceptable therapeutic levels. The purpose of this review was to explain the role of scaffolds in targeted drug delivery to bone tissue for the treatment of osteoporosis. © 2022, International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.
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