A Novel Non-Enzymatic Biosensor Based on Ti-Metallic Glass Thin Film: The Blood Glucose Oxidation Approach Publisher

Summary: Ti-based metallic glass (Ti-MG) thin film on SPCE enables non-enzymatic glucose biosensing with high electrocatalytic activity, low charge transfer resistance, and linear response from 2–8 mM. #Biosensors #GlucoseMonitoring #Nanomaterials

Sarafbidabad M¹ ; Jazi H¹ ; Rafienia M²
Source: Journal of Medical Signals and Sensors Published:2020

Abstract

Background: Material selection is a key issue for the fabrication of non-enzymatic electrode in glucose biosensors. Metallic glass (MG) as an advanced innovative material can provides many basic structural requirements of electrodes. A novel non-enzymatic biosensor based on Ti57Cu28{Zr0.95-Hf0.05}XSi15-XMG (Ti-MG) thin film was introduced for glucose oxidation. Methods: The Ti-MG thin film was deposited on the carbon substrate of screen-printed carbon electrode (SPCE), and the Ti-MG modified SPCE was fabricated as Ti-MG/SPCE. The morphology and structure of the Ti-MG thin film were characterized by field emission scanning electron microscope and X-ray diffraction. Electrochemical evaluations were studied by electrochemical impedance spectroscopy and cyclic voltammetry. Results: The Ti-MG was sputtered on the carbon substrate in the form of a porous spongy thin film with 285 nm thickness and nanoparticles with average diameter size of 110 nm. The Ti-MG/SPCE showed low charge transfer resistance to the electron transfer and high electrocatalytic activity toward the oxidation of glucose in PBS (pH = 7.4) solution. This biosensor exhibited good analytical performance with a linear range from 2 to 8 mM glucose and sensitivity of 0.017 μA mM-1. Conclusion: The experimental results indicate that Ti-MG thin film has a high ability to electron transfer and glucose oxidation for the development of non-enzymatic glucose biosensors. © 2020 Isfahan University of Medical Sciences(IUMS). All rights reserved.