Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Telomere Structure and Its Role in Dna Damage and Genetic Disorders



Kheirollahi M1 ; Koulivand L2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Inherited Diseases Research Center AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Genetics and Molecular Biology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Telomeres are special structures at the ends of chromosomes, especially in eukaryotes, that include repetitive sequences of deoxyribonucleic acid (DNA) and non-nucleosomal proteins. These structures are essential to protect chromosomes from recombination and degradation. Telomeres are gene-poor repetitive sequences, but they are close to the more gene-rich subtelomeric regions. Proteins associated with telomeres are able to interact directly with the TTAGGG repeats and also can bind to other factors to form large protein complexes. These proteins are involved in DNA repair and telomere stability. Therefore, defects in the synthesis of these proteins could induce imperfections in telomere maintenance and DNA repair; and accordingly, should cause a number of genetic syndromes.
Related Docs
1. Telomere, Regulation and Tumorigenesis, Telomere Territory and Cancer (2013)
2. The Role of Telomere in Cell; Telomere Dysfunction and Tumorigenesis, Journal of Isfahan Medical School (2013)
3. Telomeric Repeat-Containing Rna (Terra) and Human Diseases, Journal of Isfahan Medical School (2015)
4. Acute Coronary Syndrome: Role of the Telomere Dynamic, African Journal of Biotechnology (2010)
5. A Novel Pathogenic Variant in an Iranian Ataxia Telangiectasia Family Revealed by Next-Generation Sequencing Followed by in Silico Analysis, Journal of the Neurological Sciences (2017)
6. Telomerase and Therapy of Brain Tumors, Journal of Isfahan Medical School (2014)
Experts (# of related papers)
View all Related Experts
Majid Kheirollahi (4)
Fariborz Khorvash (1)