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The Role of Non-Nmda Receptor of Glutamate in Cuneiform Nucleus on Cardiovascular Response in Anesthetized Rats



Shafei MN1, 2 ; Nasimi A1 ; Alaei H1 ; Pourshanazari AA3
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Rafsanjan, Iran

Source: Pharmacologyonline Published:2009

Abstract

Cuneiform nucleus (CnF) is a reticular area of the midbrain that involved in the cardiovascular functions. It was shown that electrical and chemical stimulation of the CnF caused an increase in arterial blood pressure and excitation of sympathetic vasomotor discharge. However, there is not any study on cardiovascular effects of the glutamate and its receptors subtypes in the CnF. In the present study we investigated the cardiovascular effects of glutamate and its non-NMDA receptor in the CnF of rat. Rats were anesthetized and instrumented with an arterial catheter. Blood pressure (BP) and heart rate (HR) were recorded throughout each experiment. The drugs (50nl) were microinjected into the CnF. The maximum change was compared with control and pre-injection. Unpaired t test and pair t test was used for data analysis. Microinjection of glutamate into CnF produced two types of responses: 1) short pressor and bradycardic; 2) long pressor and tacycardic responses. Microinjection CNQX alone had no significant cardiovascular effect but coinjection of CNQX and glutamate has similar but with smaller attenuation compared to that of glutamate. Cardiovascular effects of the CnF may be mediated through glutamate receptors, but the role of non-NMDA receptor is not important.
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