Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Rosuvastatin on Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Publisher



Moeinzadeh F1 ; Jafarpishe MS2 ; Rezaee M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nephrology, School of Medicine AND Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2020


Abstract

Background: Contrast-induced acute kidney injury (CI-AKI) is an important issue in patients who are candidate for using contrast media in order to do diagnostic and therapeutic imagining. This study aimed to investigate the effect of rosuvastatin on the development of contrast-induced acute kidney injury in patients with chronic kidney disease performing computed tomography (CT) scan with contrast media. Methods: In this clinical trial study, 402 patients with chronic kidney disease who underwent CT scan with contrast in Alzahra hospital, Isfahan, Iran, during the years 2018-2019 were studied. Patients were divided into two groups, patients in the first group received 20 mg rosuvastatin 24 hours prior to CT scan and 10 mg rosuvastatin tablets daily for two consecutive days. The second group received the placebo. Findings: There was a significant difference in creatinine and glomerular filtration rate (eGFR) after CT scan (P < 0.050). The mean of creatinine was lower, and the mean of eGFR was higher in the intervention group than placebo after the intervention (P < 0.050). The frequency of contrast-induced acute kidney injury in the intervention group was 1%, and in the placebo group was 4% (P = 0.059). Conclusion: Rosuvastatin can reduce the risk of contrast-induced acute kidney injury after using contrast media, including increase in creatinine, and decrease in eGFR. © 2020 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Short Term High Dose Atorvastatin for the Prevention of Contrast-Induced Nephropathy in Patients Undergoing Computed Tomography Angiography, ARYA Atherosclerosis (2014)
2. A Randomized Trial of Saline Hydration to Prevent Contrast-Induced Nephropathy in Patients on Regular Captopril or Furosemide Therapy Undergoing Percutaneous Coronary Intervention., Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2012)
3. Comparison Between the Efficacy of High Dose Short-Term Statin Therapy and Normal Saline in Prevention of Contrast-Induced Nephropathy Among Patients Receiving Iodixanol, Journal of Isfahan Medical School (2012)
4. Captopril for Prevention of Contrast Induced Nephropathy in Patients Undergoing Coronary Angioplasty: A Double Blind Placebo Controlled Clinical Trial, Journal of Research in Medical Sciences (2005)
5. Atorvastatin and Prevention of Contrast Induced Nephropathy Following Coronary Angiography, Journal of Research in Medical Sciences (2015)
6. Application of Systemic Inflammation Score for the Assessment of Contrast-Induced Acute Kidney Injury; a Review, Journal of Nephropathology (2024)
7. Administration of N-Acetylcysteine for Contrast-Induced Acute Kidney Injury; an Updated Mini-Review, Journal of Nephropharmacology (2024)
8. Contrast-Induced Nephropathy; a Literature Review, Journal of Nephropathology (2014)
Experts (# of related papers)
View all Related Experts
Azar Baradaran (3)
Sam Mirfendereski (3)
Other Related Docs
9. Comparison Between Theophylline, N-Acetylcysteine, and Theophylline Plus N-Acetylcysteine for the Prevention of Contrast-Induced Nephropathy, ARYA Atherosclerosis (2015)
10. Silymarin for the Prevention of Contrast-Induced Nephropathy: A Placebo-Controlled Clinical Trial, International Journal of Preventive Medicine (2016)
11. The Role of Diuretics and Angiotensin-Converting Enzyme Inhibitors on Contrast- Induced Nephropathy in Patients After Percutaneous Coronary Intervention, Journal of Isfahan Medical School (2007)
12. Ameliorative Effect of Melatonin Against Contrast Media Induced Renal Tubular Cell Injury, Pakistan Journal of Medical Sciences (2014)
13. Preventive Effects of Pimpinella Anisum L. and Dracocephalum Moldavica L. Hydroalcoholic Extract Against Acute Contrast-Induced Nephropathy, Current Traditional Medicine (2023)
14. Contrast-Associated Acute Kidney Injury in Elderly; a Mini-Review on Nursing Prospectives, Journal of Renal Injury Prevention (2021)
15. Influence of the Timing of Cardiac Catheterization and Amount of Contrast Media on Acute Renal Failure After Cardiac Surgery, Journal of Research in Medical Sciences (2011)
16. The Preventive Effect of Berberis Vulgaris Extract on Contrast-Induced Acute Kidney Injury, Journal of Nephropathology (2017)
17. Pentoxifylline and Prevention of Contrast-Induced Nephropathy: Is It Efficient in Patients With Myocardial Infarction Undergoing Coronary Angioplasty?, ARYA Atherosclerosis (2016)
18. Does Metabolic Syndrome Increase Contrast‑Induced Nephropathy in Patients With Normal Renal Function?, Journal of Research in Medical Sciences (2024)
19. Survey of Ct Radiation Doses and Iodinated Contrast Medium Administration: An International Multicentric Study, European Radiology (2024)
20. Ameliorative Effect of Green Tea Against Contrast-Induced Renal Tubular Cell Injury, Iranian Journal of Kidney Diseases (2015)
21. The Effect of the Various Doses of Atorvastatin on Renal Tubular Cells; an Experimental Study, Journal of Nephropathology (2016)
22. Improving Effects of Green Tea on Renal Nephrotoxicity, Journal of Isfahan Medical School (2016)
23. Is High Preprocedural Renal Resistive Index Sensitive Enough to Predict Iodine Contrast-Induced Nephropathy in Patients Receiving Intra-Arterial Iodinate Contrast?, Current Problems in Diagnostic Radiology (2021)
24. Coronary Ct Angiography by Modifying Tube Voltage and Contrast Medium Concentration: Evaluation of Image Quality and Radiation Dose, Echocardiography (2019)