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Improving Effects of Green Tea on Renal Nephrotoxicity



Nasri H1 ; Khodadadi S2 ; Moradi M2 ; Ahmadi A3 ; Kohi G4 ; Rafieiankopaei M5
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nickan Research Institute, Isfahan, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran

Source: Journal of Isfahan Medical School Published:2016

Abstract

Background: Contrast media-induced acute renal damage could lead to renal failure; so, recently much attention has been made on the efficacy of medicinal plants in prevention and treatment of various diseases, especially in kidney and liver complications. Methods: Forty rats were randomly divided into four groups of 10 consisting of control, contrast media, contrast media plus green tea and green tea pretreatment and contrast media group, respectively. After collecting blood samples from lateral tail vein blood urea nitrogen (BUN) and serum creatinine were measured for assessing tubular nephrotoxicity. Findings: In the second group creatinine level was significantly higher than other groups (P ≤ 0.05). Conclusion: Green tea can provide an applicable intervention approach in individuals with a risk for contrast induced acute kidney injury. So, further preclinical investigations are necessary to confirm the efficiency of this herb against various injurious substances to the renal tubular cells. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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