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Effect of Dairy Products Fortified With Vitamin D3 on Restless Legs Syndrome in Women With Premenstrual Syndrome, Abdominal Obesity and Vitamin D Deficiency: A Pilot Study Publisher Pubmed



Sharifan P1, 2 ; Sahranavard T2 ; Rashidmayvan M1 ; Darroudi S13 ; Fard MV4 ; Mohammadhasani K4 ; Mansoori A5, 6 ; Eslami S7 ; Safarian M1 ; Afshari A1 ; Bagherniya M8 ; Tayefi M9 ; Khademrezaiyan M10 ; Ghazizadeh H2, 3 Show All Authors
Authors
  1. Sharifan P1, 2
  2. Sahranavard T2
  3. Rashidmayvan M1
  4. Darroudi S13
  5. Fard MV4
  6. Mohammadhasani K4
  7. Mansoori A5, 6
  8. Eslami S7
  9. Safarian M1
  10. Afshari A1
  11. Bagherniya M8
  12. Tayefi M9
  13. Khademrezaiyan M10
  14. Ghazizadeh H2, 3
  15. Ferns G11
  16. Rezaie M1
  17. Ghayourmobarhan M1, 3, 12
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Science, Gonabad, Iran
  5. 5. Department of Applied Mathematics, School of Mathematical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
  6. 6. Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Norwegian Center for e-health Research, University Hospital of North Norway, Tromso, Norway
  10. 10. Clinical Research Development Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Brighton and Sussex Medical School, Division of Medical Education, Brighton, United Kingdom
  12. 12. Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran
  13. 13. Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: BMC Women's Health Published:2024


Abstract

Backgrounds: Restless legs syndrome (RLS) is an unpleasant condition that affects the quality of life of patients. Its prevalence in increased in women with premenstrual syndrome (PMS). Vitamin D plays a key role in female reproduction through its impact on calcium homeostasis and neurotransmitters. We aimed to evaluate the effect of dairy products fortified with Vitamin D3 on RLS in women with PMS. Materials and methods: We conducted a 2.5-month, randomized, total-blinded clinical trial to evaluate the effectiveness of low-fat milk and yogurt fortified with vitamin D on RLS in women with PMS. Among 141 middle-aged women with abdominal obesity, 71 and 70 cases received fortified and non-fortified low-fat dairy products, respectively. All subjects completed a Symptoms Screening Tool (PSST) and RLS questionnaires. Results: The results showed that in the women with severe PMS (PSST > 28), serum levels of vitamin D increased significantly following vitamin D fortification. The mean restless legs score in the severe PMS subgroup (PSST > 28) was significantly lower after the intervention (p < 0.05. Serum Vitamin D levels significantly differed between intervention and control groups in all individuals (PSST < 19, PSST 19–28, and PSST > 28) (p < 0.05), but no significant differences were found between RLS scores of the intervention and control groups in the three PMS subgroups (p > 0.05). Conclusion: Fortifying dairy products with vitamin D3 can increase the serum levels of vitamin D and reduce the RLS severity in women with severe PMS, but not in other groups. © The Author(s) 2024.
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