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The Effects of Low-Fat Dairy Products Fortified With 1500 Iu Vitamin D3 on Serum Liver Function Biomarkers in Adults With Abdominal Obesity: A Randomized Controlled Trial Publisher Pubmed



Sharifan P1, 2 ; Darroudi S3 ; Rafiee M2 ; Roustai Geraylow K2 ; Hemmati R2 ; Rashidmayvan M1, 2 ; Safarian M1 ; Eslami S4 ; Vatanparast H5 ; Zarefeizabadi R3 ; Mohammadibjgiran M3 ; Ghazizadeh H3 ; Khorasanchi Z1, 2 ; Bagherniya M6 Show All Authors
Authors
  1. Sharifan P1, 2
  2. Darroudi S3
  3. Rafiee M2
  4. Roustai Geraylow K2
  5. Hemmati R2
  6. Rashidmayvan M1, 2
  7. Safarian M1
  8. Eslami S4
  9. Vatanparast H5
  10. Zarefeizabadi R3
  11. Mohammadibjgiran M3
  12. Ghazizadeh H3
  13. Khorasanchi Z1, 2
  14. Bagherniya M6
  15. Ferns G7
  16. Rezaie M1
  17. Ghayourmobarhan M1, 3
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad, Iran
  3. 3. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. College of Pharmacy and Nutrition, School of Public Health, University of Saskatchewan, Saskatoon, Canada
  6. 6. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Division of Medical Education, Brighton and Sussex Medical School, Room 346, Mayfield House, SSX, Falmer, Brighton, BN1 9PH, United Kingdom

Source: Journal of Health, Population and Nutrition Published:2023


Abstract

Introduction: Vitamin D deficiency has been reported to affect liver function biomarkers. This study was aimed to investigate the effect of consuming vitamin D fortified low-fat dairy products on liver function tests in adults with abdominal obesity. Methods: This total blinded randomized controlled trial was undertaken on otherwise healthy abdominally obese adults living in Mashhad, Iran. Milk and yogurt were fortified with 1500 IU vitamin D3 nano-capsules. Participants were randomized to receive fortified milk (n = 73), plain milk (n = 73), fortified yogurt (n = 69), and plain yogurt (n = 74) for 10 weeks. Blood samples were taken at baseline and at the end of the study to assess serum levels of vitamin D, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase (ALP), and Gamma glutamyl transferase. Results: A total of 289 participants completed the study (54% female). The groups were homogenous in terms of age, sex, weight, energy intake, and physical activity level (p-value > 0.05). After the trial, vitamin D serum levels were significantly increased in both groups receiving fortified products (both p < 0.001). There was a significant time*group effect only in serum ALP (p < 0.001). Conclusion: Consumption of dairy products fortified by 1500 IU vitamin D3 might have detrimental effects on serum levels of some liver enzymes in individuals with abdominal obesity. Further studies needed to determine these effects and underlying mechanisms. Trial registration: IRCT20101130005280N27 . © 2023, BioMed Central Ltd., part of Springer Nature.
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