Effects of Folic Acid Supplementation on Oxidative Stress Markers: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Publisher



Asbaghi O¹ ; Ghanavati M² ; Ashtarylarky D³ ; Bagheri R⁴ ; Rezaei Kelishadi M⁵ ; Nazarian B⁶ ; Nordvall M⁷ ; Wong A⁷ ; Dutheil F⁸ ; Suzuki K⁹ ; Naeini AA⁵ Show Affiliations
Source: Antioxidants Published:2021

Abstract

(1) Background: This systematic review and meta‐analysis aimed to assess the effects of folic acid supplementation on oxidative stress markers. (2) Methods: Online database including PubMed, Scopus, Web of Science, and Cochrane were searched up to January 2021, to retrieve randomized controlled trials (RCTs) which examined the effect of folic acid supplementation on markers of oxidative stress. Meta‐analyses were carried out using a random‐effects model. I2 index was used to evaluate the heterogeneity of RCTs. (3) Results: Among the initial 2322 studies that were identified from electronic databases search, 13 studies involving 1013 participants were eligible. Pooled effect size from 13 studies indicated that folic acid supplementation elicits a significant rise in serum concentrations of glutathione (GSH) (WMD: 219.01 umol/L, 95% CI 59.30 to 378.71, p = 0.007) and total antioxidant capacity (TAC) (WMD: 91.70 umol/L, 95% CI 40.52 to 142.88, p < 0.001) but has no effect on serum concentrations of nitric oxide (NO) (WMD: 2.61 umol/L, 95% CI −3.48 to 8.72, p = 0.400). In addition, folic acid supplementation significantly reduced serum concentrations of malondialdehyde (MDA) (WMD: −0.13 umol/L, 95% CI −0.24 to −0.02, p = 0.020). (4) Conclusions: This meta‐analysis study suggests that folic acid supplementation may significantly improve markers within the antioxidative defense system by increasing serum concentrations of GSH and TAC and decreasing serum concentrations of MDA. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.