Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Novel Nanosized Gd3+-Algd-G2 -C595: In Vivo Dual Selective Muc-1 Positive Tumor Molecular Mr Imaging and Therapeutic Agent Publisher



Mirzaei M1 ; Mohagheghi M2 ; Shahbazigahrouei D3 ; Khatami A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Institute Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Nanomedicine and Nanotechnology Published:2012


Abstract

Scope of this study is to synthesize a nano-dendrimer and its conjugate with C595 MAb against breast cancer cell, followed by its chelating agent with Gd3+. At the end, its use as a dual nanosized probe for detection and treatment was investigated. Anti-MUC-1 MAb C595 was coupled to a biodegradable biocompatible anionic linear globular dendrimer, ALGDG2, Poly ethylene glycol PEG core and citric acid shell followed by loading with Gd3+ to make novel MR imaging contrast agents. Anticancer effects and MR imaging parameters of the prepared nanoconjugate was investigated in vitro: cell toxicity, apoptosis and TNF-alpha, hemolysis, LDH evaluations as well as toxicity, biodistribution and MR imaging of cancer place were investigated. Results showed good tumor accumulation and detection, no in vivo toxicity, and potential selective anti-breast cancer activity. In conclusion, findings of this study showed that Gd3+-ALGDG2 -C595 nano-probe is potentially both, a selective breast molecular imaging tool as well as a therapeutic agent. Further, subsequent clinical trials appear warranted. © 2012 Mirzaei M, et al.
Related Docs
View other Related Docs
1. Technetium-99M Chelator-Free Radiolabeling of Specific Glutamine Tumor Imaging Nanoprobe: In Vitro and in Vivo Evaluations, International Journal of Nanomedicine (2018)
2. Detection of Muc1-Expressing Ovarian Cancer by C595 Monoclonal Antibody-Conjugated Spions Using Mr Imaging, The Scientific World Journal (2013)
3. Gadolinium-Diethylenetriaminepenta-Acetic Acid Conjugated With Monoclonal Antibody C595 As New Magnetic Resonance Imaging Contrast Agents for Breast Cancer (Mcf-7) Detection, Iranian Biomedical Journal (2006)
4. As1411 Aptamer-Anionic Linear Globular Dendrimer G2-Iohexol Selective Nano-Theranostics, Scientific Reports (2017)
5. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
6. A Literature Review on Multimodality Molecular Imaging Nanoprobes for Cancer Detection, Polish Journal of Medical Physics and Engineering (2019)
7. Study the Anti-Muc1 Antibody-Based Iron Oxide Nanoparticles on Three-Dimension Spheroid and Breast Cancer (Mcf-7) Cell Imaging, Polish Journal of Medical Physics and Engineering (2019)
8. Anti-Cd24 Bio Modified Pegylated Gold Nanoparticles As Targeted Computed Tomography Contrast Agent, Advanced Pharmaceutical Bulletin (2018)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (24)
Jaleh Varshosaz (17)
Other Related Docs
9. Methotrexate-Conjugated to Polymer Quantum Dot for Cytotoxicity Effect Improved Against Mcf-7 and Hela Cells, Medicinal Chemistry Research (2018)
10. In Vitro Study of Spions-C595 As Molecular Imaging Probe for Specific Breast Cancer (Mcf-7) Cells Detection, Iranian Biomedical Journal (2017)
11. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
12. Antitumor Activity of Raloxifene-Targeted Poly(Styrene Maleic Acid)-Poly (Amide-Ether-Ester-Imide) Co-Polymeric Nanomicelles Loaded With Docetaxel in Breast Cancer-Bearing Mice, Investigational New Drugs (2018)
13. Co-Delivery of Dasatinib and Mir-30A by Liposomes Targeting Neuropilin-1 Receptors for Triple-Negative Breast Cancer Therapy, Journal of Materials Chemistry B (2024)
14. As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice, Nanomedicine (2018)
15. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
16. Ultrasound-Guided Chemoradiotherapy of Breast Cancer Using Smart Methotrexate-Loaded Perfluorohexane Nanodroplets, Nanomedicine: Nanotechnology, Biology, and Medicine (2023)
17. Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review, ACS Applied Nano Materials (2022)
18. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
19. Mxenes in Photomedicine: Advances and Prospects, Chemical Communications (2022)
20. Facile, Rapid and Efficient Isolation of Circulating Tumor Cells Using Aptamer-Targeted Magnetic Nanoparticles Integrated With a Microfluidic Device, RSC Advances (2022)
21. Ultrasound Responsive Gd-Dota/Doxorubicin-Loaded Nanodroplet As a Theranostic Agent for Magnetic Resonance Image-Guided Controlled Release Drug Delivery of Melanoma Cancer, European Journal of Pharmaceutical Sciences (2022)
22. Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy, Seminars in Cancer Biology (2022)
23. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
24. Hollow Mesoporous Prussian Blue Nanoparticles for in Vivo Synergistic Chemo-Photothermal Cancer Therapy and Dual-Mode Magnetic Resonance/Fluorescence Imaging, ACS Applied Nano Materials (2024)
25. Investigation of Different Targeting Decorations Effect on the Radiosensitizing Efficacy of Albumin-Stabilized Gold Nanoparticles for Breast Cancer Radiation Therapy, European Journal of Pharmaceutical Sciences (2019)
26. Design, Synthesis, and Comparison of Pla-Peg-Pla and Peg-Pla-Peg Copolymers for Curcumin Delivery to Cancer Cells, Polymers (2023)
27. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
28. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
29. An Insight Into Fluorescence and Magnetic Resonance Bioimaging Using a Multifunctional Polyethyleneimine-Passivated Gadocarbon Dots Nanoconstruct Assembled With As1411, Microchimica Acta (2023)
30. Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice, Recent Patents on Anti-Cancer Drug Discovery (2019)
31. Fluorescence Resonance Energy Transfer Monitoring of Ph-Responsive Doxorubicin Release From Carbon Dots/Aptamer Functionalized Magnetic Mesoporous Silica, Nanomedicine (2021)
32. Anti-Cancer Activity of Biotin-Polyoxomolybdate Bioconjugate, Eurasian Journal of Medicine and Oncology (2020)
33. Optical, Physical and Quantum Properties of Gold Nanoparticles and Its Applications in Diagnosis and Treatment of Cancers, Journal of Isfahan Medical School (2015)
34. The Effect of Folic Acid-Targeted Nanocarriers in Ultrasound Imaging-Guided Sonodynamic Therapy of Human Cervical Carcinoma (Hela): In Vitro Study, Koomesh (2023)
35. Nanobodies; New Molecular Instruments With Special Specifications for Targeting, Diagnosis and Treatment of Triple-Negative Breast Cancer, Cancer Cell International (2022)
36. Mn(Ii) & Gd(Iii) Deferrioxamine Complex Contrast Agents & Temozolomide Cancer Prodrug Immobilized on Folic Acid Targeted Graphene/Polyacrylic Acid Nanocarrier: Mri Efficiency, Drug Stability & Interactions With Cancer Cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
37. Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells, Journal of Inorganic and Organometallic Polymers and Materials (2024)
38. Novel Mr Imaging Nanoprobe for Hepatocellular Carcinoma Detection Based on Manganese–Zinc Ferrite Nanoparticles: In Vitro and in Vivo Assessments, Journal of Cancer Research and Clinical Oncology (2023)
39. Hierarchical Multifunctional Graphene Oxide Cancer Nanotheranostics Agent for Synchronous Switchable Fluorescence Imaging and Chemical Therapy, Microchimica Acta (2020)
40. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
41. A Review on Application of Novel Solid Nanostructures in Drug Delivery, Journal of Nano Research (2018)
42. As1411 Aptamer Conjugated Gold Nanoclusters As a Targeted Radiosensitizer for Megavoltage Radiation Therapy of 4T1 Breast Cancer Cells, RSC Advances (2018)
43. Recent Advances in Nanomaterials Development for Nanomedicine and Cancer, ACS Applied Bio Materials (2021)
44. Targeted Delivery of Doxorubicin to Breast Cancer Cells by Magnetic Lhrh Chitosan Bioconjugated Nanoparticles, International Journal of Biological Macromolecules (2016)
45. Her-2 Aptamer-Targeted Ecoflex® Nanoparticles Loaded With Docetaxel Promote Breast Cancer Cells Apoptosis and Anti-Metastatic Effect, IET Nanobiotechnology (2019)
46. Assessment of Ph Responsive Delivery of Methotrexate Based on Phema-St-Peg-Da Nanohydrogels, Macromolecular Research (2021)
47. In Vitro Study of Sonodynamic Therapy Using Gemcitabine-Loaded Peg-Gold Nanoparticles Against Mcf-7 Breast Cancer Cells, BioNanoScience (2024)
48. Trastuzumab Conjugated Porphyrin-Superparamagnetic Iron Oxide Nanoparticle: A Potential Ptt-Mri Bimodal Agent for Herceptin Positive Breast Cancer, Photodiagnosis and Photodynamic Therapy (2020)
49. Hyaluronic Acid-Conjugated Gliadin Nanoparticles for Targeted Delivery of Usnic Acid in Breast Cancer: An in Vitro / in Vivo Translational Study, Journal of Drug Delivery Science and Technology (2023)
50. Folic Acid-Functionalized Gadolinium-Loaded Phase Transition Nanodroplets for Dual-Modal Ultrasound/Magnetic Resonance Imaging of Hepatocellular Carcinoma, Talanta (2021)