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Mucormycosis in Iran: A Six-Year Retrospective Experience Publisher Pubmed



Dolatabadi S1 ; Ahmadi B2 ; Rezaeimatehkolaei A3 ; Zarrinfar H4 ; Skiada A5 ; Mirhendi H6 ; Nashibi R7 ; Niknejad F8 ; Nazeri M9 ; Rafiei A3 ; Gharaghani M10 ; Erami M11 ; Taghipour S12 ; Piri F3 Show All Authors
Authors
  1. Dolatabadi S1
  2. Ahmadi B2
  3. Rezaeimatehkolaei A3
  4. Zarrinfar H4
  5. Skiada A5
  6. Mirhendi H6
  7. Nashibi R7
  8. Niknejad F8
  9. Nazeri M9
  10. Rafiei A3
  11. Gharaghani M10
  12. Erami M11
  13. Taghipour S12
  14. Piri F3
  15. Makimura K13
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Engineering, Sabzevar, Iran
  2. 2. Department of Medical Laboratory Sciences, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  3. 3. Department of Medical Mycology, School of Medicine, Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
  6. 6. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Health Research Institute, Infectious and Tropical Diseases Research Center, Infectious Diseases Department, Razi Teaching Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. 8. Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  9. 9. Department of Medical Parasitology and Mycology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  10. 10. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  11. 11. Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran
  12. 12. Department of Medical Parasitology and Mycology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  13. 13. Division of Clinical Laboratory Medicine, Graduate School of Medical Care and Technology, Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan

Source: Journal de Mycologie Medicale Published:2018


Abstract

Mucormycosis is a devastating infection caused by Mucoralean fungi (Mucormycotina, Mucorales). Data concerning the global epidemiology of mucormycosis are scarce and little is known about the characteristics of mucormycosis in Iran. In this study, we aimed to understand the distribution of this infection in Iran retrospectively and to ascertain whether the patterns of infection are associated with specific host factors or not. A total of 208 cases were included in this study occurring during 2008–2014 and were validated according to (EORTC/MSG) criteria. A rising trend as significant increase from 9.7% in 2008 to 23.7% in 2014 was observed. The majority of patients were female (51.4%) with median age of 50 and the infections were seen mostly in autumn season (39.4%). Diabetes mellitus (75.4%) was the most common underlying condition and sinus involvement (86%) was the mostly affected site of infection. Amphotericin B (AmB) was the drug of choice for the majority of cases. Sixty four isolates did not show any growth in the lab and only 21 cases were evaluated by ITS sequencing, among them; Rhizopus arrhizus var. arrhizus was the dominant species. Considering the high mortality rate of mucormycosis, early and accurate diagnosis, with the aid of molecular methods may provide accurate treatments and improve the survival rate. Therefore, increased monitoring and awareness of this life-threatening disease is critical. © 2018 Elsevier Masson SAS
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