Isfahan University of Medical Sciences

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Residual Goiter in Semirom; Iodine Status and Thiocyanate Overload Do Not Play a Role Publisher Pubmed



Keshteli AH1, 2 ; Hashemipour M2 ; Amini M2 ; Siavash M2 ; Aminorroaya A2 ; Rezvanian H2 ; Kachuei A2 ; Kelishadi R3
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Source: Journal of Tropical Pediatrics Published:2009


Abstract

This study was performed to investigate the role of thiocyanate overload in the etiology of endemic goiter in schoolchildren of Semirom, Iran. A total of 1828 schoolchildren were selected by multi-stage random sampling. Urinary iodine concentration (UIC) and urinary thiocyanate (USCN) were measured in a group of these children. The median UIC was 18.5 μg/dl. The mean ± SD of USCN in goitrous and nongoitrous subjects did not differ significantly (0.75 ± 0.78 mg/dl vs. 0.63 ± 0.40 mg/dl; p = 0.30). Finally, we concluded that neither iodine deficiency nor thiocyanate overload contributed to the high prevalence of goiter in Semirom. The role of other goitrogenic factors should be investigated in this region. © The Author [2009]. Published by Oxford University Press. All rights reserved.