Immunocompromised Patients: Review of the Most Common Infections Happened in 446 Hospitalized Patients



Meidani M¹ ; Naeini AE² ; Rostami M² ; Sherkat R³ ; Tayeri K¹ Show Affiliations
Source: Journal of Research in Medical Sciences Published:2014

Abstract

Background: Immunodefi ciency is a heterogenous group of diseases aff ecting diff erent components of the immune system. Patterns of infection, etiology and organ involvement are not similar in this risky population. Th is study was conducted to determine the prevalence of congenital and acquiring immunodefi ciencies and also recognizing the most common infections and aff ected organs. Materials and Methods: In a retrospective, cross-sectional survey, during 2006-2012, we reviewed all hospital records with any kind of immunodefi ciency admitted in, all departments of university referral hospital, Isfahan, Iran. Results: Various immunodefi ciencies, sorted by prevalence, were as below: Primary immunodefi ciency diseases (PIDs) 122 (27.4%), lymphohematogenous malignancy (LHM) 105 (23.5%), solid cancer 56 (12.6%), human immunodefi ciency virus/acquired immunodefi ciency syndrome 64 (14.5%), non-cytotoxic immunosuppresion 94 (21%), and splenectomy 5 (1.2%). Common sources of infection were blood, lungs and buccal cavity. Conclusion: Th e most frequent type of immunodefi ciency was PIDs and LHM. Infection continues to be a major problem in all variety of immunodefi ciency.