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Diversity of Malignancies in Patients With Different Types of Inborn Errors of Immunity Publisher



Tavakol M1 ; Delavari S2, 3 ; Salami F2, 3 ; Ansari S1 ; Rasouli SE1 ; Chavoshzadeh Z4 ; Sherkat R5 ; Ahanchian H6 ; Aleyasin S7 ; Esmaeilzadeh H8 ; Moazzen N9 ; Shafiei A10 ; Abolnezhadian F11 ; Iranparast S12, 13 Show All Authors
Authors
  1. Tavakol M1
  2. Delavari S2, 3
  3. Salami F2, 3
  4. Ansari S1
  5. Rasouli SE1
  6. Chavoshzadeh Z4
  7. Sherkat R5
  8. Ahanchian H6
  9. Aleyasin S7
  10. Esmaeilzadeh H8
  11. Moazzen N9
  12. Shafiei A10
  13. Abolnezhadian F11
  14. Iranparast S12, 13
  15. Ebrahimi S14
  16. Moeini Shad T2, 3
  17. Pashangzadeh S2, 3
  18. Nazari F2, 15
  19. Rezaei A2, 3
  20. Saeediboroujeni A16
  21. Nabavi M17
  22. Arshi S17
  23. Fallahpour M17
  24. Bemanian M17
  25. Sharafian S4
  26. Shokri S17
  27. Eshaghi S18
  28. Nazari S19
  29. Shamsian BS20
  30. Dargahi Malamir M21
  31. Khazaei R21
  32. Ashkevari P1
  33. Khavandegar A1
  34. Haghi S22
  35. Esmaeili M2, 3
  36. Abolhassani H2, 23
  37. Rezaei N2, 3
Show Affiliations
Authors Affiliations
  1. 1. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Pediatric Infections Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Clinical Research Development Unit of Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Department of Pediatric Immunology and Allergy, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Department of Immunology, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Pediatrics, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  12. 12. Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  13. 13. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  14. 14. Department of Immunology and Allergy, Kerman University of Medical Sciences, Kerman, Iran
  15. 15. Immunology Today, Universal Scientific Education and Research Network (USERN), Tehran, Iran
  16. 16. Department of Microbiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
  17. 17. Department of Allergy and Clinical Immunology, Rasool E Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  18. 18. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  19. 19. Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  20. 20. Pediatric Hematologist-Oncologist, Congenital Hematological Disorders Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  21. 21. Department of Pulmonology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  22. 22. Department of Hematology and Oncology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  23. 23. Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden

Source: Allergy, Asthma and Clinical Immunology Published:2022


Abstract

Genetic defects in the development, maturation, and/or function of the immune cells can lead to Inborn errors of immunity (IEI) which may predispose patients to malignancies. The overall risk for cancer in children with IEI ranges from 4 to 25% and the type of malignancy is highly dependent on the specific mutant gene underlying IEI. We investigated 3056 IEI patients registered in the Iranian national registry between the years 1999 and 2020 in this retrospective cohort study. The frequency of malignancy and its association with the type of IEI in these patients were evaluated. A total of 82 IEI patients with malignancy were enrolled in this study. Among them, predominantly lymphoma was the most common type of malignancy (67.1%), followed by leukemia (11%), and cancers of the head and neck (7.3%). Among identified lymphoma cancers, non-Hodgkin’s lymphomas were the most frequent type (43.9%) followed by different subtypes of Hodgkin’s lymphoma (23.2%). Solid tumors (18.3%) appeared to be very heterogeneous by type and localization. The correlation between the type of malignancy and survival status and the association between the type of malignancy and IEI entities were unremarkable. The awareness of the association between the presence of IEI and cancer highlights the importance of a synergistic effort by oncologists and immunologists in the early diagnosis of malignancy and personalized therapeutic strategies in IEI patients. © 2022, The Author(s).
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