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The Sesame Lignan Sesamin Attenuates Vascular Dysfunction in Streptozotocin Diabetic Rats: Involvement of Nitric Oxide and Oxidative Stress Publisher Pubmed



Baluchnejadmojarad T1 ; Roghani M2 ; Jalali Nadoushan MR3 ; Vaez Mahdavi MR2 ; Kalalianmoghaddam H1 ; Roghanidehkordi F4 ; Dariani S1 ; Raoufi S1
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Neurophysiology Research Center and Department of Physiology, Shahed University, Tehran, Iran
  3. 3. Department of Pathology, School of Medicine, Shahed University, Tehran, Iran
  4. 4. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: European Journal of Pharmacology Published:2013


Abstract

The effect of chronic administration of sesamin was studied on aortic reactivity of streptozotocin diabetic rats. Male diabetic rats received sesamin for 7 weeks after diabetes induction. Contractile responses to KCl and phenylephrine and relaxation response to acetylcholine were obtained from aortic rings. Maximum contractile response of endothelium-intact rings to phenylephrine was significantly lower in sesamin-treated diabetic rats relative to untreated diabetics and endothelium removal abolished this difference. Meanwhile, endothelium-dependent relaxation to acetylcholine was significantly higher in sesamin-treated diabetic rats as compared to diabetic ones and pretreatment of rings with nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester significantly attenuated the observed response. Two-month diabetes also resulted in an elevation of malondialdehyde and decreased superoxide dismutase activity and sesamin treatment significantly improved these changes. Therefore, chronic treatment of diabetic rats with sesamin could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and via attenuation of oxidative stress and tissue integrity of endothelium is necessary for its beneficial effect. © 2012 Elsevier B.V. All rights reserved.
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