Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin- Induced Diabetic Rats Publisher Pubmed



Roghani M1 ; Vaez Mahdavi MR1 ; Jalalinadoushan MR2 ; Baluchnejadmojarad T3 ; Naderi G4 ; Roghanidehkordi F5 ; Taghi Joghataei M6 ; Kord M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
  2. 2. Department of Pathology, School of Medicine, Shahed University, Tehran, Iran
  3. 3. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biochemistry, School of Medicine, Shahed University, Tehran, Iran
  5. 5. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Tehran, Iran
  6. 6. Department of Anatomy and Neuroscience, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Phytotherapy Research Published:2013


Abstract

The effect of chronic daidzein, a soybean isoflavone, on aortic reactivity of streptozotocin-diabetic rats was studied. Male diabetic rats received daidzein for 7 weeks a week after diabetes induction. Contractile responses to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh) were obtained from aortic rings. Maximum contractile response of endothelium-intact rings to PE was significantly lower in daidzein-treated diabetic rats relative to untreated diabetic rats, and endothelium removal abolished this difference. Endothelium-dependent relaxation to ACh was significantly higher in daidzein-treated diabetic rats as compared with diabetic rats and pretreatment of rings with nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester and/or indomethacin attenuated it. Two-month diabetes also resulted in an elevation of malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity, and daidzein treatment significantly reversed the increased MDA content and reduced activity of SOD. Therefore, chronic treatment of diabetic rats with daidzein could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and prostaglandin-related pathways, and via attenuation of oxidative stress in aortic tissue and endothelium integrity seems essential for this effect. Copyright © 2012 John Wiley & Sons, Ltd.
Experts (# of related papers)
Other Related Docs
11. Anti-Diabetic Effects of Walnut Oil on Alloxan-Induced Diabetic Rats, African Journal of Pharmacy and Pharmacology (2011)
15. Effect of Fenugreek Seeds on Blood Glucose and Lipid Profiles in Type 2 Diabetic Patients, International Journal for Vitamin and Nutrition Research (2009)
16. Antioxidant Plants and Diabetes Mellitus, Journal of Research in Medical Sciences (2015)
40. Anti-Oxidant Effect of Flavonoids on the Susceptibility of Ldl Oxidation, Molecular and Cellular Biochemistry (2003)