The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years

The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years Publisher Pubmed

Nikbakht M¹ ; Ahmadi F² ; Vaseghi G³ ; Talasaz AH⁴ ; Eshraghi A⁵ ; Naderi J⁶ ; Daneshme MA²

Show Affiliations

1. Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
2. Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran
3. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
4. Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Clinical Pharmacy, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran
6. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Clinical Pharmacology Published:2017

Abstract

Background: N-acetylcysteine (NAC) is an amino acid that contains a cysteine group and is currently used widely in various fields of medical research especially in cardiology. In this review, potential benefits of NAC in the aggregation of platelet and reperfusion injury are evaluated. Methods: The available evidence was collected by searching Scopus, Pub-Med, Medline, Cochrane central register of controlled trials, and Cochrane database systematic reviews. Our searching was performed without time limitation and only English language articles were included in this review. Key words used as search terms included “N-acetylcysteine”, “platelet aggregation”, “reperfusion injury”. Results: Over the past decade, several investigations were carried out to ascertain reperfusion injury and antiplatelet properties of NAC, and in this article the results of investigations in both models (human and animal) were addressed in detail. The results revealed that NAC has an important antiplatelet property in animal models while this effect is not very significant in human models and needs more investigations. However, its reperfusion injury in both models is worth noticing. Conclusion: Due to the limited data about effectiveness of NAC in both human and animal as antiplatelet agent, more investigation is needed to evaluate NAC efficacy in platelet aggregation and reperfusion injury especially in human studies in the future. © 2017 Bentham Science Publishers.

2. Protective Effect of N-Acetylcysteine on Kidney As a Remote Organ After Skeletal Muscle Ischemia-Reperfusionspi; [Efeito Protetor Da N-Acetilcisteina No Rim Como Um Orgao Remoto Musculo Esqueletico Apos Isquemia-Reperfusao], Acta Cirurgica Brasileira (2012)

3. N-Acetylcysteine Prevents Kidney and Lung Disturbances in Renal Ischemia/ Reperfusion Injury in Rat, International Journal of Preventive Medicine (2013)

4. Administration of N-Acetylcysteine for Contrast-Induced Acute Kidney Injury; an Updated Mini-Review, Journal of Nephropharmacology (2024)

5. The Effect of N-Acetylcysteine in Prime Solution on Reducing Damage to the Myocardium in Open Heart Surgery, Journal of Isfahan Medical School (2024)

6. A Double-Blinded, Placebo-Controlled, Multicenter Clinical Trial of N -Acetylcysteine for Preventing Amphotericin B-Induced Nephrotoxicity, Expert Opinion on Drug Metabolism and Toxicology (2015)

7. The Effect of N-Acetylcysteine in Prime Solution on Preventing Renal Failure During Cardiopulmonary Bypass Surgery, Journal of Isfahan Medical School (2021)

Experts (# of related papers)

View all Related Experts

Gholamreza Jahanshahi (2)

Mehran Shahzamani (2)

Style	Citing Format
MLA	Nikbakht M, et al.. "The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years." Current Clinical Pharmacology, vol. 12, no. 2, 2017, pp. 83-91.
APA	Nikbakht M, Ahmadi F, Vaseghi G, Talasaz AH, Eshraghi A, Naderi J, Daneshme MA (2017). The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years. Current Clinical Pharmacology, 12(2), 83-91.
Chicago	Nikbakht M, Ahmadi F, Vaseghi G, Talasaz AH, Eshraghi A, Naderi J, Daneshme MA. "The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years." Current Clinical Pharmacology 12, no. 2 (2017): 83-91.
Harvard	Nikbakht M et al. (2017) 'The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years', Current Clinical Pharmacology, 12(2), pp. 83-91.
Vancouver	Nikbakht M, Ahmadi F, Vaseghi G, Talasaz AH, Eshraghi A, Naderi J, et al.. The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years. Current Clinical Pharmacology. 2017;12(2):83-91.
BibTex	@article{ author = {Nikbakht M and Ahmadi F and Vaseghi G and Talasaz AH and Eshraghi A and Naderi J and Daneshme MA}, title = {The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years}, journal = {Current Clinical Pharmacology}, volume = {12}, number = {2}, pages = {83-91}, year = {2017} }
RIS	TY - JOUR AU - Nikbakht M AU - Ahmadi F AU - Vaseghi G AU - Talasaz AH AU - Eshraghi A AU - Naderi J AU - Daneshme MA TI - The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years JO - Current Clinical Pharmacology VL - 12 IS - 2 SP - 83 EP - 91 PY - 2017 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract