Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Frequency of Candida Species Isolated From Patients in Children’S Medical Center, Tehran, Iran Publisher



Charsizadeh A1 ; Nikmanesh B2 ; Ahmadi B3 ; Jalalizand N1 ; Jafari Z1 ; Rahmani M4 ; Kordbacheh P1 ; Mirhendi H5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Departments of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Laboratory Science, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Laboratory Sciences, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  4. 4. Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Departments of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Archives of Pediatric Infectious Diseases Published:2018


Abstract

Background: Candida species originating from either endogenous or exogenous sources are one of the main causes of opportunistic infections. Colonization is an important independent risk factor for invasive candidiasis, and many patients admitted to neonatal intensive care unit (NICU) and pediatric intensive care unit (PICU) are colonized with Candida species that may result in invasive candidiasis. Awareness among clinicians about various aspects of colonization is critical to optimal management. The aim of this study was to determine the frequency and species distribution of Candida strains isolated from predisposed patients hospitalized at Children’s Medical Center (CMC), Tehran, Iran. Methods: From June 2014 to June 2016, 347 Candida isolates were collected from 341 patients either hospitalized in different wards or referred as outpatients. The yeasts were identified by colony color characteristics using CHROMagar Candidamediumand by amplification of the ITS1-5.8S rDNA-ITS2 region in DNA extracted from each isolate followed by analysis of species specific electrophoretic patterns of PCR products digested with the restriction enzyme MspI. Results: Of the 341 patients, 213 were males and 128 were females. Most samples were obtained from the 1 – 12-month age group, and the majority of samples represented urine (n = 182), throat swabs (n = 57), and stool samples (n = 53), respectively. The samples were mostly from patients in general wards. The most commonly isolated species was C. albicans (77%), followed by C. tropicalis (8.4%), C. parapsilosis (7.5%), C. glabrata (2.3%), C. kefyr (1.7%), C. krusei (1.1%), C. lusitaniae (0.6%), C. guilliermondii (0.3%), C. albicans + C. parapsilosis (1.4%), and C. albicans + C. glabrata (0.3%). Conclusions: C. albicans is the most common species isolated from children in Iran, followed by C. tropicalis and C. parapsilosis, a prevalence pattern that is relatively different from studies in other countries. Neonates and infants 1 - 12 months of age hospitalized in ICU, were more colonized by Candida species than other groups. © 2017, Pediartric Infections Research Center.
Related Docs
View other Related Docs
1. Microbial Epidemiology of Candidaemia in Neonatal and Paediatric Intensive Care Units at the Children's Medical Center, Tehran, Mycoses (2018)
2. Candidemia in Children Caused by Uncommon Species of Candida, Archives of Pediatric Infectious Diseases (2018)
3. Species Distribution and Antifungal Susceptibility Profile of Candida Isolates From Blood and Other Normally Sterile Foci From Pediatric Icu Patients in Tehran, Iran, Medical Mycology (2020)
4. Utilization of Size Polymorphism in Its1 and Its2 Regions for Identification of Pathogenic Yeast Species, Journal of Medical Microbiology (2017)
5. Candida Urinary Tract Infection Among Icu Patients in Isfahan, Iran, Archives of Clinical Infectious Diseases (2019)
6. Frequency of Uncommon Clinical Yeast Species Confirmed by Its-Sequencing, Archives of Clinical Infectious Diseases (2019)
7. Overview on the Infections Related to Rare Candida Species, Pathogens (2022)
8. Diagnosis of Candida Species Isolated From Patients With Vaginal Candidiasis and Healthy Individuals Based on Clinical Symptoms and Paraclinical Evidences, Journal of Isfahan Medical School (2012)
Experts (# of related papers)
View all Related Experts
Seyed Hossein Mirhendi Esfahani (34)
Rasoul Mohammadi (34)
Other Related Docs
9. Epidemiology, Species Distribution, Antifungal Susceptibility, and Outcome of Candidemia in Intensive Care Units in Isfahan, Iran, Current Medical Mycology (2022)
10. Frequency of Candida Species in the Oral Cavity of Narcotics and Stimulants Smokers in Isfahan, Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method, Advanced Biomedical Research (2020)
11. Cross-Sectional Study of Candidemia From Isfahan, Iran: Etiologic Agents, Predisposing Factors, and Antifungal Susceptibility Testing, Journal of Research in Medical Sciences (2021)
12. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
13. Identification of Candida Species Isolated From Renal Transplant Recipients With Candiduria, International Journal of Organ Transplantation Medicine (2016)
14. Candida Infections Among Neutropenic Patients, Caspian Journal of Internal Medicine (2016)
15. In Vitro Antifungal Susceptibility Pattern of Candida Species Isolated From Gastroesophageal Candidiasis, Gastroenterology and Hepatology from Bed to Bench (2021)
16. The Frequency of Candiduria in Hospitalized Patients at Nephrology Department, Labbafinejad Hospital, Tehran, Iran, Journal of Isfahan Medical School (2017)
17. Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated From Clinical Samples, Jundishapur Journal of Microbiology (2017)
18. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)
19. The Matching Rate of the Frequency of the Isolated Candida Species Calculated by Morphological and Molecular Methods in Patients With Vaginitis, Journal of Isfahan Medical School (2017)
20. Epidemiology and Antifungal Susceptibility of Candida Species Isolated From 10 Tertiary Care Hospitals in Iran, Microbiology Spectrum (2022)
21. Identification of Candida Species Isolated From Candiduria Patients Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism in Isfahan, Iran, Journal of Isfahan Medical School (2016)
22. The Frequency of Oral Candidiasis in Children and Adolescents With Leukemia in Isfahan Province, Iran, Journal of Isfahan Medical School (2017)
23. Low Level of Antifungal Resistance in Iranian Isolates of Candida Glabrata Recovered From Blood Samples in a Multicenter Study From 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of Pdr1, Antimicrobial Agents and Chemotherapy (2019)
24. Identification and Frequency of Candida Species in Patients With Different Forms of Candidiasis in Isfahan, Using Pcr-Rflp Method, Journal of Isfahan Medical School (2011)
25. Evaluation of Prevalence of New Candida Species (C. Orthopsilosis and C. Metapsilosis) Among C. Parapsilosis Group Isolated From Patients by Pcr-Rflp of Sadh Gene in Iran, Journal of Isfahan Medical School (2011)
26. Differentiation of Candida Albicans Complex Species Isolated From Invasive and Non-Invasive Infections Using Hwp1 Gene Size Polymorphism, Current Medical Mycology (2021)
27. Antifungal Susceptibility Analysis of Clinical Isolates of Candida Parapsilosis in Iran, Iranian Journal of Public Health (2016)
28. Molecular Characterization and Antifungal Susceptibilitytesting of Candida Nivariensis From Blood Samples – an Iranian Multicentre Study and a Review of the Literature, Journal of Medical Microbiology (2019)
29. Candidemia Among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida Parapsilosis, Journal of Fungi (2022)
30. Molecular Epidemiology and Antifungal Susceptibility Profile in Nakaseomyces Glabrata Species Complex: A 5-Year Countrywide Study, Journal of Clinical Laboratory Analysis (2024)
31. A 3-Year Study of Candida Infections Among Patients With Malignancy: Etiologic Agents and Antifungal Susceptibility Profile, Frontiers in Cellular and Infection Microbiology (2023)
32. Catheter-Associated Blood Stream Infections Due to Candida Pararugosa in a Patient With Acute Myeloid Leukemia: A Case Report, Brazilian Journal of Microbiology (2023)
33. Molecular Identification of Candida Species Isolated From Gastrooesophageal Candidiasis in Tehran, Iran, Gastroenterology and Hepatology from Bed to Bench (2015)
34. Yeast Species in the Respiratory Samples of Covid-19 Patients; Molecular Tracking of Candida Auris, Frontiers in Cellular and Infection Microbiology (2024)
35. Identification of Candida Species and Antifungal Susceptibility in Cancer Patients With Oral Lesions in Ahvaz, Southern West of Iran, Advanced Biomedical Research (2020)
36. South Asian (Clade I) Candida Auris Meningitis in a Paediatric Patient in Iran With a Review of the Literature, Mycoses (2022)
37. Molecular Characterization of Candida Dubliniensis and Candida Albicans in the Oral Cavity of Drug Abusers Using Duplex Polymerase Chain Reaction, Current Medical Mycology (2018)
38. Rapid Detection of Candida Species in Bronchoalveolar Lavage Fluid From Patients With Pulmonary Symptoms, Brazilian Journal of Microbiology (2016)
39. Candida Africana Vulvovaginitis: Prevalence and Geographical Distribution, Journal de Mycologie Medicale (2020)
40. Caspofungin-Non-Susceptible Candida Orthopsilosis Isolated From Onychomycosis in Iran, Iranian Journal of Public Health (2017)
41. Epidemiologic and Antifungal Susceptibility Profile of Candiduria Among Patients Hospitalized in the Nephrology and Intensive Care Unit Wards, Tehran, Iran, Jundishapur Journal of Microbiology (2022)
42. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)
43. An Alarming Rise of Non-Albicans Candida Species and Uncommon Yeasts in the Clinical Samples; a Combination of Various Molecular Techniques for Identification of Etiologic Agents, BMC Research Notes (2019)
44. Clinical and Mycological Study of Vulvovaginal Candidiasis (Vvc); Identification of Clinical Isolates by Polymerase Chain Reaction-Fragment Size Polymorphyim (Pcr-Fsp) Technique, Archives of Clinical Infectious Diseases (2017)
45. Antifungal Activity of Anethum Graveolens Extract and Atrovastatin Against Candida Species Compared to Fluconazole, Journal of Isfahan Medical School (2015)
46. Candida Africana and Candida Dubliniensis As Causes of Pediatric Candiduria: A Study Using Hwp1 Gene Size Polymorphism, AIMS Microbiology (2020)
47. Species Distribution and Susceptibility Profiles of Oral Candidiasis in Hematological Malignancy and Solid Tumor Patients, Brazilian Journal of Microbiology (2023)
48. Characterization of Beta-Tubulin Dna Sequences Within Candida Parapsilosis Complex, Current Medical Mycology (2018)
49. Nosocomial Urinary Tract Infections in a Tertiary Hospital; Preliminary Study of Antibiotics Susceptibility Testing and Pathogen Types, Anti-Infective Agents (2024)
50. Evaluation of Rapid Diagnosis of Candidemia by Agglutination Test Using Gold Nanoparticles, Journal of Isfahan Medical School (2022)