Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Hydralazine on Duration of Soft Tissue Local Anesthesia Following Dental Treatment: A Randomized Clinical Trial Pubmed



Esfahani OF1, 2 ; Pouraboutaleb MF3 ; Khorami B1, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Periodontology, School of Dentistry, Kerman University of Medical Sciences, Iran
  2. 2. Department of Periodontology, Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Iran
  3. 3. School of Pharmacy, Pharmaceutical Sciences Research Center, Iran
  4. 4. Department of Oral and Maxillofacial Surgery, Dental Faculty, Isfahan (Khorasgan) Branch, Islamic Azad University, Iran

Source: General Dentistry Published:2015


Abstract

Prolonged numbness following routine dental treatments can cause difficulties in speaking and swallowing and may result in inadvertent biting of soft tissues. Local injection of vasodilator agents may represent a solution to this problem. The aim of this study was to evaluate the effect of submucosal injection of hydralazine hydrochloride (HCl) on the duration of oral soft tissue anesthesia after routine dental treatment. This randomized, single-blinded, controlled clinical trial included 50 patients who received inferior alveolar nerve block (2% lidocaine with 1:100,000 epinephrine) for simple restorative treatment. Upon completion of the dental treatment, patients randomly received a hydralazine HCl or sham injection in the same site as the local anesthetic injection. The reversal time to normal sensation of soft tissues (lips, tongue, and perioral skin) was evaluated and reported every 5 minutes by the patients, who followed an assessment protocol that they were taught in advance of treatment. Median recovery times in the hydralazine group and the sham group were 81.4 (SD, 3.6) and 221.8 (SD, 6.3) minutes, respectively. Based on Kaplan-Meier survival analysis, the duration of soft tissue anesthesia in the 2 groups was significantly different (P < 0.0001). By 1 hour after the reversal injection, 76% of subjects receiving hydralazine HCl had returned to normal intraoral and perioral sensation, but none of the subjects in the sham group reported normal sensation. Based on these results, submucosal injection of hydralazine HCl can be considered a safe and effective method to reduce the duration of local anesthetic-induced soft tissue numbness and the related functional problems. © 2015 by the Academy of General Dentistry. All rights reserved.
Related Docs
View other Related Docs
1. Effect of Phentolamine As Reversal of Soft-Tissue Anesthesia on Post-Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial, Iranian Endodontic Journal (2019)
2. Anaesthetic Efficacy of 2% Lidocaine With Different Concentrations of Epinephrine (1:80,000 and 1:200,000) in Intraligamentary Injection After a Failed Primary Inferior Alveolar Nerve Block: A Randomized Double-Blind Study, Acta Odontologica Scandinavica (2020)
3. Effect of Chlordiazepoxide and Oxazepam on the Success Rate of Mandibular Nerve Block Anesthesia: A Randomized Double Blind Control Trial, Advances in Environmental Biology (2014)
4. Effect of Preoperative Alprazolam on the Success of Inferior Alveolar Nerve Block for Teeth With Irreversible Pulpitis, Journal of Endodontics (2012)
5. Effect of Sodium Bicarbonate-Buffered Lidocaine on the Success of Inferior Alveolar Nerve Block for Teeth With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-Blind Study, Journal of Endodontics (2015)
6. Removal of Laryngeal Mask Airway: Awake or Deep Anesthesia?, Journal of Research in Medical Sciences (2005)
7. Evaluating the Prophylactic Effect of Magnesium Sulfate and Combination of Midazolam and Ketamine for Prevention of Shivering During Regional Anaesthesia, Journal of Isfahan Medical School (2016)
8. Anesthetic Efficacy of Gow-Gates Nerve Block, Inferior Alveolar Nerve Block, and Their Combination in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Clinical Trial, Journal of Endodontics (2018)
Experts (# of related papers)
View all Related Experts
Masoud Saatchi (16)
Nasser Kaviani (14)
Other Related Docs
9. Injection of Lidocaine Alone Versus Lidocaine Plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evaluation, Pain Research and Management (2021)
10. Anesthetic Success Rate of Inferior Alveolar Nerve Block for Mandibular Molars With Symptomatic Irreversible Pulpitis in Women Taking Antidepressants, Iranian Endodontic Journal (2022)
11. Comparison of the Effect of Thiopental Sodium Supplementation and Hypertonic Saline 5% Alone or Their Combination on Intracranial Pressure Changes During Craniotomy Surgeries, Journal of Isfahan Medical School (2019)
12. Effect of Pre-Cooling on Pain Associated With Dental Injections in Children: A Systematic Review, Journal of Evidence-Based Dental Practice (2021)
13. Anesthetic Efficacy of Articaine and Ketamine for Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis: A Prospective Randomized Double-Blind Study, Iranian Endodontic Journal (2017)
14. Effects of Buffering and Preparation Time of Topical Anesthetics on Pain of Injection Into Oral Mucosa, Journal of Isfahan Medical School (2012)
15. The Effect of Orally Administered Ketamine on Requirement for Anesthetics and Postoperative Pain in Mandibular Molar Teeth With Irreversible Pulpitis., Journal of oral science (2011)
16. Effect of Intraligamentary Tramadol Hydrochloride on Anesthetic Success During Endodontic Management of Mandibular Molars: A Randomized Clinical Controlled Trial, European Endodontic Journal (2024)
17. Postoperative Residual Block in Postanesthesia Care Unit More Than Two Hours After the Administration of a Single Intubating Dose of Atracurium, Journal of Research in Medical Sciences (2011)
18. Comparative Evaluation of Bispectral Index System After Sedation With Midazolam and Propofol Combined With Remifentanil Versus Ketamine in Uncooperative During Dental Procedures, Dental Research Journal (2016)
19. The Efficacy of Prophylactic Intravenous Aminophylline, Paracetamol or Aminophylline and Paracetamol in Prevention of Post Spinal Headache in Lower Extremity Surgeries Compared to the Control Group, Tehran University Medical Journal (2019)
20. Professional Attitudes and Practice of Pediatric Dentists About the Use of Local Anesthesia for the Treatment of Children Under General Anesthesia, Anesthesiology and Pain Medicine (2024)
21. Anaesthetic Efficacy of Lidocaine/Clonidine for Inferior Alveolar Nerve Block in Patients With Irreversible Pulpitis, International Endodontic Journal (2017)
22. A Comparative Study of the Effect of Adding Dexmedetomidine, Dexamethasone and Sodium Bicarbonate to Ropivacaine in Ultrasound Guided Supraclavicular Block on the Quality of the Block in Orthopedic Surgery, Archives of Anesthesiology and Critical Care (2024)
23. Effect of Magnesium Sulphate Added to Lidocaine on Inferior Alveolar Nerve Block Success in Patients With Symptoms of Irreversible Pulpitis: A Prospective, Randomized Clinical Trial, International Endodontic Journal (2020)
24. Oral Clonidine Premedication Decreases Intraoperative Bleeding in Patients Undergoing Endoscopic Sinus Surgery, Journal of Research in Medical Sciences (2005)
25. The Frequency and the Etiology of Re-Treatment in Patients and Candidates for Dental Procedure Under General Anesthesia, Dental Research Journal (2023)
26. Supplementing Epidural Lidocaine With Midazolam: Effect on Sensorymotor Block Level, Acta Anaesthesiologica Taiwanica (2004)
27. Effect of Vibration Devices on Pain Associated With Dental Injections in Children: A Systematic Review and Meta-Analysis, Australian Dental Journal (2021)
28. Attenuation of the Pressor Response to Direct Laryngoscopy and Tracheal Intubation: Oral Clonidine Vs. Oral Gabapentin Premedication, Journal of Research in Medical Sciences (2011)
29. Effect of Low-Dose Ketamine Versus Lidocaine on Hemodynamic Response to Endotracheal Intubation in General Anesthesia: A Prospective, Triple-Blinded, Randomized Controlled Trial, Tehran University Medical Journal (2023)
30. A Comparative Study of Predicting Difficult Intubation by Six Indexes of Thyromental Height (Tmh), Acromioaxillary-Suprasternal Notch Index (Aasi), Modified Mallampati Test (Mmt), Upper Lip Biting Test (Ulbt), Height to Thyromental Distance Ratio (Rhtmd), and Neck Circumference to Thyromental Height Ratio (Nc/Tmh) in Patients Undergoing General Anesthesia, Journal of Isfahan Medical School (2019)
31. Comparison of Success Rate and Onset Time of Two Different Anesthesia Techniques, Medicina Oral, Patologia Oral y Cirugia Bucal (2015)
32. Comparison of Oral Melatonin and Midazolam As Premedication in Children Undergoing General Anesthesia for Dental Treatment, Anesthesiology and Pain Medicine (2018)
33. The Comparison of Spinal Anesthesia With General Anesthesia on the Postoperative Pain Scores and Analgesic Requirements After Elective Lower Abdominal Surgery: A Randomized, Double-Blinded Study, Journal of Research in Medical Sciences (2013)
34. Comparison Between the Effect of Bupivacaine-Pethidine and Bupivacaine-Ketamine As Preemptive in Bilateral Infraorbital Nerve Block on Postoperative Pain Relief in Infants Undergoing Clef Lip Repair, a Controlled Study, Journal of Isfahan Medical School (2017)
35. A Comparison of Sedation Quality With Midazolam-Ketamine Versus Propofol-Ketamine During Phacoemulsification Surgery, Tehran University Medical Journal (2021)
36. Determination of Sensitivity of Male Wistar Rats to an Equal Dose of Ketamine/Xylazine Injection at Anesthetic Dose in a Chronic Model of Hypernatremia in Comparison With Control Group, Saudi Medical Journal (2007)
37. Anesthetic Efficacy of Lidocaine/Ketorolac in Inferior Alveolar Nerve Block in Patients With Irreversible Pulpitis: A Randomized Clinical Trial, European endodontic journal (2020)
38. Effect of Fentanyl on the Success of Inferior Alveolar Nerve Block for Teeth With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial, Giornale Italiano di Endodonzia (2022)
39. Topical Lidocaine Plus Diclofenac As a Local Anesthetic Agent in Central Venous Catheterization; a Randomized Controlled Clinical Trial, Archives of Academic Emergency Medicine (2021)
40. Comparing the Intraoperative Pain Severity in Phacoemulsification Cataract Surgery Under the Topical Anesthesia and Systemic Sedation in Patients With Hairy and Normal Eyebrow, Journal of Isfahan Medical School (2015)
41. Prophylactic Effects of Intravenous Dexamethasone and Lidocaine on Attenuating Hemodynamic-Respiratory and Pain Complications in Children Undergoing Cleft Palate Repair Surgery With General Anesthesia, Journal of Pain and Palliative Care Pharmacotherapy (2020)
42. Comparative Study of the Effect of Oral Chloral Hydrate and Intranasal Fentanyl on Sedation in Children for Electroencephalography, Iranian Journal of Child Neurology (2023)
43. The Analgesic Effect of Three Different Doses of Nitroglycerine When Added to Lidocaine for Intravenous Regional Anesthesia in Trauma Patients; [Travma Hastalarinda Intravenoz Rejyonel Anestezi Icin Lidokaine Eklenmesi Durumunda Uc Farkli Nitrogliserin Dozunun Analjezik Etkisi], Ulusal Travma ve Acil Cerrahi Dergisi (2011)
44. The Effect of Hypernatremic State on Anesthesia: Male Wistar Rat, Tehran University Medical Journal (2008)
45. Analgesic Efficacy of Dexamethasone and Dexmedetomidine As an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study, Archives of Anesthesiology and Critical Care (2024)
46. Investigating Sevoflurane, Remifentanil, and Propofol Effects on Recovery of Patients With Movement Disorders Under General Anesthesia, Journal of Advanced Pharmacy Education and Research (2024)
47. Premedication With Oral Dextromethorphan Reduces Intra-Operative Morphine Requirement, Journal of Research in Medical Sciences (2005)
48. Bispectoral Index Scores of Pediatric Patients Under Dental Treatment and Recovery Conditions: Study of Children Assigned for General Anesthesia Under Propofol and Isofloran Regimes, Dental Research Journal (2016)
49. Effect of Intraosseous Injection Versus Inferior Alveolar Nerve Block As Primary Pulpal Anaesthesia of Mandibular Posterior Teeth With Symptomatic Irreversible Pulpitis: A Prospective Randomized Clinical Trial, Acta odontologica Scandinavica (2018)
50. A Comparative Study of the Effect of Anesthesia Induction With the Use of Four Drug Combinations Including 'Propofol,' 'Etomidate-Propofol,' 'Thiopental,' and 'Midazolam-Thiopental' on Hemodynamic Changes During the Insertion of Laryngeal Mask in Eye Surgery, Advanced Biomedical Research (2022)