The Effect of Lutein and Zeaxanthine on Dyslipidemia: A Meta-Analysis Study Publisher Pubmed



Ghasemi F¹ ; Navab F² ; Rouhani MH² ; Amini P¹ ; Shokrimashhadi N¹ Show Affiliations
Source: Prostaglandins and Other Lipid Mediators Published:2023

Abstract

Aims: The relationship between circulating Lutein and zeaxanthin (L/Z) concentrations, and plasma lipoproteins has been indicated by observational studies. However, the beneficial impact of L/Z administration on dyslipidemia are unclear. This meta-analysis aimed to investigate the effect of oral intake of L/Z on circulating total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), as well as high-density lipoprotein-cholesterol (HDL-C) levels. Methods: We electronically assessed all eligible interventional studies through different electronic databases, including PubMed, Scopus, ISI –Web of Science, and Cochrane library until Jun 2021. After identifying the quality of each included randomized controlled trials, they were evaluated by assessing the risk-difference between treatment and control groups by pooling available data on net change of serum LDL-C, HDL-C, and Cholesterol. Results: L/Z supplementation has null effect on circulating levels of TC (WMD: −3.82 95% CI: −13.83, 6.18; I-square: 85.2%), and LDL-C (WMD: −4.54; 95% CI: −11.5, 2.48; I-square: 83.9%). In contrast, L/Z treatment could significantly increase HDL-C levels in older adults (WMD: 4.06; 95% CI: 0.64, 7.48; I-square: 50.7%). Conclusion: L/Z administration could be an effective treatment for improving circulating HDL-C concentration in elderly adults. © 2022 Elsevier Inc.