Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways

Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways Publisher Pubmed

Lim HF^{1, 2} ; Tan NS² ; Dehghan R^{3, 4} ; Shen M⁵ ; Liew MF^{1, 2} ; Bee SWL⁶ ; Sia YY³ ; Liu J^{2, 3} ; Khor CC^{3, 7} ; Kwok I^{5, 8} ; Ng LG^{5, 8, 9, 10} ; Angeli V¹¹ ; Dorajoo R^{3, 12}

Show Affiliations

1. Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore
2. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
3. Agency for Science, Technology and Research, Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Singapore
4. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
5. Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
6. Department of Diagnostic Radiology, National University Hospital, National University Health System, Singapore, Singapore
7. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore
8. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
9. State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Sciences & Peking Union Medical College, Tianjin, China
10. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
11. Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine and Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 119077, Singapore
12. Duke-NUS Medical School Singapore, Health Services and Systems Research, Singapore, Singapore

Source: Lung Published:2022

Abstract

Telomere attrition is an established ageing biomarker and shorter peripheral blood leukocyte telomere length has been associated with increased risks of respiratory diseases. However, whether telomere length in disease-relevant sputum immune cells of chronic respiratory disease patients is shortened and which pathways are dysfunctional are not clear. Here we measured telomere length from sputum samples of bronchiectasis and asthmatic subjects and determined that telomere length in sputum of bronchiectasis subjects was significantly shorter (Beta = − 1.167, PAdj = 2.75 × 10−4). We further performed global gene expression analysis and identified genes involved in processes such as NLRP3 inflammasome activation and regulation of adaptive immune cells when bronchiectasis sputum telomere length was shortened. Our study provides insights on dysfunctions related to shortened telomere length in sputum immune cells of bronchiectasis patients. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Related Docs

1. Acute Coronary Syndrome: Role of the Telomere Dynamic, African Journal of Biotechnology (2010)

2. Proteome Analysis of Human Neutrophil Granulocytes From Patients With Monogenic Disease Using Data-Independent Acquisition, Molecular and Cellular Proteomics (2019)

3. Association Between +4259 T>G and -574 G>T Polymorphisms of Tim-3 With Asthma in an Iranian Population, Iranian Journal of Allergy, Asthma and Immunology (2017)

4. Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy, Cell (2021)

5. Expression of Terra in Different Grades of Astrocytoma, Journal of Isfahan Medical School (2015)

6. Central Obesity Accelerates Leukocyte Telomere Length (Ltl) Shortening in Apparently Healthy Adults: A Systematic Review and Meta-Analysis, Critical Reviews in Food Science and Nutrition (2023)

7. Human Carmil2 Deficiency Underlies a Broader Immunological and Clinical Phenotype Than Cd28 Deficiency, Journal of Experimental Medicine (2023)

8. Comparison of Terra Expression in Human Brain Tumors; [«Confronto Dell’Espressione Dell’Rna Non Codificante Denominato Terra Nei Tumori Cerebrali Umani»], European Journal of Oncology (2015)

Experts (# of related papers)

View all Related Experts

Rasoul Salehi (2)

Majid Kheirollahi (2)

Style	Citing Format
MLA	Lim HF, et al.. "Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways." Lung, vol. 200, no. 3, 2022, pp. 401-407.
APA	Lim HF, Tan NS, Dehghan R, Shen M, Liew MF, Bee SWL, Sia YY, Liu J, Khor CC, Kwok I, Ng LG, Angeli V, Dorajoo R (2022). Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways. Lung, 200(3), 401-407.
Chicago	Lim HF, Tan NS, Dehghan R, Shen M, Liew MF, Bee SWL, Sia YY, et al.. "Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways." Lung 200, no. 3 (2022): 401-407.
Harvard	Lim HF et al. (2022) 'Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways', Lung, 200(3), pp. 401-407.
Vancouver	Lim HF, Tan NS, Dehghan R, Shen M, Liew MF, Bee SWL, et al.. Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways. Lung. 2022;200(3):401-407.
BibTex	@article{ author = {Lim HF and Tan NS and Dehghan R and Shen M and Liew MF and Bee SWL and Sia YY and Liu J and Khor CC and Kwok I and Ng LG and Angeli V and Dorajoo R}, title = {Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways}, journal = {Lung}, volume = {200}, number = {3}, pages = {401-407}, year = {2022} }
RIS	TY - JOUR AU - Lim HF AU - Tan NS AU - Dehghan R AU - Shen M AU - Liew MF AU - Bee SWL AU - Sia YY AU - Liu J AU - Khor CC AU - Kwok I AU - Ng LG AU - Angeli V AU - Dorajoo R TI - Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways JO - Lung VL - 200 IS - 3 SP - 401 EP - 407 PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract