Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status in Women With Gestational Diabetes: A Randomized Controlled Clinical Trial Publisher



Jafarnejad S1 ; Saremi S2 ; Jafarnejad F3 ; Arab A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran
  2. 2. Department of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Health Information Management, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Nutrition and Metabolism Published:2016


Abstract

Objective. This trial aims to examine the effects of a Probiotic Mixture (VSL#3) on glycemic status and inflammatory markers, in women with GDM. Materials and Methods. Over a period of 8 weeks, 82 women with gestational diabetes were randomly assigned to either an intervention group (n = 41) which were given VSL#3 capsule or to a control group which were given placebo capsule (n = 41). Fasting plasma glucose, homeostatic model assessment of insulin resistance, glycosylated hemoglobin, high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-6, Interferon gamma, and interleukin-10 were measured before and after the intervention. Results. After 8 wk of supplementation FPG, HbA1c, HOMA-IR, and insulin levels remained unchanged in the probiotic and placebo groups. The comparison between the two groups showed no significant differences with FPG and HbA1c, but there were significant differences in insulin levels and HOMA-IR (16.6 ± 5.9; 3.7 ± 1.5, resp.). Unlike the levels of IFN-g (19.21 ± 16.6), there was a significant decrease in levels of IL-6 (3.81 ± 0.7), TNF-α (3.10 ± 1.1), and hs-CRP (4927.4 ± 924.6). No significant increase was observed in IL-10 (3.11 ± 5.7) in the intervention group as compared with the control group. Conclusions. In women with GDM, supplementation with probiotics (VSL#3) may help to modulate some inflammatory markers and may have benefits on glycemic control. © 2016 Sadegh Jafarnejad et al.
Related Docs
View other Related Docs
1. The Effects of Probiotics and Synbiotic Supplementation on Glucose and Insulin Metabolism in Adults With Prediabetes: A Double-Blind Randomized Clinical Trial, Acta Diabetologica (2018)
2. Effects of Probiotic Supplementation in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis, Nutrition Reviews (2016)
3. Effect of Multispecies Probiotic Supplements on Metabolic Profiles, Hs-Crp, and Oxidative Stress in Patients With Type 2 Diabetes, Annals of Nutrition and Metabolism (2013)
4. Probiotic Supplementation in Diabetic Hemodialysis Patients Has Beneficial Metabolic Effects, Kidney International (2017)
5. Effect of Daily Consumption of Probiotic Yoghurt on Insulin Resistance in Pregnant Women: A Randomized Controlled Trial, European Journal of Clinical Nutrition (2013)
6. The Effect of Probiotic Supplementation on the Risk of Gestational Diabetes Mellitus Among High-Risk Pregnant Women: A Parallel Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Biomedicine and Pharmacotherapy (2021)
7. Effects of Probiotic Supplementation on Pancreatic Β‑Cell Function and C‑Reactive Protein in Women With Polycystic Ovary Syndrome: A Randomized Double‑Blind Placebo‑Controlled Clinical Trial, International Journal of Preventive Medicine (2015)
8. Effects of Probiotic Supplementation on Pancreatic Β‑Cell Function and C‑Reactive Protein in Women With Polycystic Ovary Syndrome: A Randomized Double‑Blind Placebo‑Controlled Clinical Trial, International Journal of Preventive Medicine (2015)
Experts (# of related papers)
View all Related Experts
Awat Feizi (18)
Gholamreza Askari (16)
Other Related Docs
9. The Effects of Probiotic and Synbiotic Supplementation on Metabolic Syndrome Indices in Adults at Risk of Type 2 Diabetes: Study Protocol for a Randomized Controlled Trial, Trials (2017)
10. The Effects of Probiotic Supplementation on Markers of Blood Lipids, and Blood Pressure in Patients With Prediabetes: A Randomized Clinical Trial, International Journal of Preventive Medicine (2014)
11. Potential Mechanisms Linking Probiotics to Diabetes: A Narrative Review of the Literature; [Mecanismos Potenciais Ligando Probioticos a Diabetes: Uma Revisao Narrativa Da Literatura], Sao Paulo Medical Journal (2017)
12. Association Between Dietary Inflammatory Potential and Risk of Developing Gestational Diabetes: A Prospective Cohort Study, Nutrition Journal (2021)
13. The Effects of 6 Mo of Supplementation With Probiotics and Synbiotics on Gut Microbiota in the Adults With Prediabetes: A Double Blind Randomized Clinical Trial, Nutrition (2020)
14. Probiotics, Prebiotics, and Synbiotics in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Clinical Trials, Diabetes/Metabolism Research and Reviews (2024)
15. Effects of Probiotics and Synbiotic on Lipid Profiles in Adults at Risk of Type 2 Diabetes: A Double-Blind Randomized Controlled Clinical Trial, Functional Foods in Health and Disease (2019)
16. Probiotic and Synbiotic Supplementation Could Improve Metabolic Syndrome in Prediabetic Adults: A Randomized Controlled Trial, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
17. Effects of Probiotic and Selenium Co-Supplementation on Lipid Profile and Glycemia Indices: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Current Nutrition Reports (2023)
18. The Effects of Pro-, Pre-, and Synbiotics Supplementation on Polycystic Ovary Syndrome: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials, Frontiers in Nutrition (2023)
19. Effect of Probiotic Soy Milk on Serum Levels of Adiponectin, Inflammatory Mediators, Lipid Profile, and Fasting Blood Glucose Among Patients With Type Ii Diabetes Mellitus, Probiotics and Antimicrobial Proteins (2017)
20. Salsalate Improves Glycemic Control in Patients With Newly Diagnosed Type 2 Diabetes, Acta Diabetologica (2013)
21. Effects of Probiotic Supplementation on Hormonal and Clinical Outcomes of Women Diagnosed With Polycystic Ovary Syndrome: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Journal of Functional Foods (2022)
22. Incidence, Risk Factors, and Pregnancy Outcomes of Gestational Diabetes Mellitus Using One-Step Versus Two-Step Diagnostic Approaches: A Population-Based Cohort Study in Isfahan, Iran, Diabetes Research and Clinical Practice (2018)
23. Associations Between Higher Egg Consumption During Pregnancy With Lowered Risks of High Blood Pressure and Gestational Diabetes Mellitus, International Journal for Vitamin and Nutrition Research (2018)
24. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
25. Brewer's Yeast Improves Glycemic Indices in Type 2 Diabetes Mellitus, International Journal of Preventive Medicine (2013)
26. Appetite Sensation Improvement by Synbiotic Supplementation in Patients With Metabolic Syndrome: A Randomized Controlled Clinical Trial, Food Science and Nutrition (2024)
27. Chronic Low-Grade Inflammation: Etiology and Its Effects, Journal of Isfahan Medical School (2016)
28. Effect of Sesame Supplementation on Body Composition and Lipid Profile in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2024)
29. Effect of Daily Consumption of Probiotic Yogurt on Oxidative Stress in Pregnant Women: A Randomized Controlled Clinical Trial, Annals of Nutrition and Metabolism (2012)
30. The Effect of Probiotics on Lipid Profile & Anthropometric Indices in Diabetic Nephropathy; a Systematic Review and Meta-Analysis of Clinical Trials, Journal of Diabetes and Metabolic Disorders (2021)
31. Therapeutic Effect of Fenugreek Supplementation on Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Clinical Trials, Heliyon (2024)
32. Effect of Synbiotics and Probiotics Supplementation on Autoimmune Diseases: A Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2021)
33. Difference in Quantities of Bifidobacteria From the Intestinal Microflora of Individuals With Type 2 Diabetes and Healthy Individuals From Iran, Journal of Isfahan Medical School (2013)
34. Effect of Vitamin E Intake on Glycemic Control and Insulin Resistance in Diabetic Patients: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition Journal (2023)
35. Dietary Insulin Load and Index in Relation to Incident Gestational Diabetes Mellitus: A Prospective Cohort Study, Scientific Reports (2024)
36. Long-Term Gaba Supplementation Regulates Diabetic Gastroenteropathy Through Gaba Receptor/Trypsin-1/Pars/Akt/Cox-2 Axis, Doklady Biochemistry and Biophysics (2024)
37. Effect of Non-Soy Legume Consumption on Inflammation and Serum Adiponectin Levels Among First-Degree Relatives of Patients With Diabetes: A Randomized, Crossover Study, Nutrition (2015)
38. The Impact of a Low Glycemic Index Diet on Inflammatory Markers and Serum Adiponectin Concentration in Adolescent Overweight and Obese Girls: A Randomized Clinical Trial, Hormone and Metabolic Research (2016)
39. Can Probiotics Supplementation Improve Glycemic and Renal Status in Diabetic Nephropathy? a Systematic Review and Meta-Analysis of Clinical Trials, Endocrine, Metabolic and Immune Disorders - Drug Targets (2022)
40. Prediction of Glucose Intolerance at 24-28 Weeks of Gestation by Glucose and Insulin Level Measurements in the First Trimester, Iranian Journal of Nursing and Midwifery Research (2015)
41. The Effects of Probiotics on Body Weight and Biomarkers of Animal, Pakistan Journal of Nutrition (2013)
42. The Effect of Okra (Abelmoschus Esculentus) on Lipid Profiles and Glycemic Indices in Type 2 Diabetic Adults: Randomized Double Blinded Trials, Phytotherapy Research (2020)
43. The Acidity of Early Pregnancy Diet and Risk of Gestational Diabetes Mellitus, Clinical Nutrition (2018)
44. Effects of Synbiotic Supplementation on Anthropometric Indices and Body Composition in Overweight or Obese Children and Adolescents: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, World Journal of Pediatrics (2023)
45. Does Fenugreek (Trigonella Foenum-Graecum) Seed Improve Inflammation, and Oxidative Stress in Patients With Type 2 Diabetes Mellitus? a Parallel Group Randomized Clinical Trial, European Journal of Integrative Medicine (2018)
46. Long Term Effects of Oral Vitamin E Supplement in Type Ii Diabetic Patients, International Journal for Vitamin and Nutrition Research (2005)
47. The Effect of Pomegranate (Punica Granatum) Supplementation on Metabolic Status in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2020)
48. Gestational Diabetes Mellitus in Plymouth, U.K.: Prevalence, Seasonal Variation and Associated Factors, Journal of Reproductive Medicine for the Obstetrician and Gynecologist (2006)
49. The Role of Probiotic Supplementation in Inflammatory Biomarkers in Adults: An Umbrella Meta-Analysis of Randomized Controlled Trials, Inflammopharmacology (2023)
50. Effect of Fermented Camel Milk on Glucose Metabolism, Insulin Resistance, and Inflammatory Biomarkers of Adolescents With Metabolic Syndrome: A Double-Blind, Randomized, Crossover Trial, Journal of Research in Medical Sciences (2018)