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A Case-Control Study on Dietary Calcium Intake and Risk of Glioma Publisher Pubmed



Yekta MF1 ; Soltani S2, 3 ; Shayanfar M4 ; Benisikohansal S3 ; Mohammadshirazi M4 ; Sharifi G5 ; Esmaillzadeh A3, 6, 7
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Students' Scientific Research Center, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Tehran, Iran
  5. 5. Department of Neurosurgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: European Journal of Cancer Prevention Published:2021


Abstract

Limited evidence exists regarding the association between dietary calcium intake and risk of glioma. The objective of this study was to determine the relationship between dietary calcium intake and risk of glioma in Iranian adults. In this hospital-based case-control study, we enrolled 128 newly-diagnosed cases of glioma and 256 age- and sex-matched controls. Patients with pathologically confirmed glioma (without any other cancers) were selected. Dietary intakes of study participants were collected through a validated 126-item food-frequency questionnaire. Dietary calcium intake was computed from dairy products in the questionnaire. Participants were categorized into quartiles of dietary calcium intake. Binary logistic regression was used to examine the association between dietary calcium intake and glioma. Higher dietary intake of calcium was associated with younger age, long duration of cell phone use, and frequent canned foods intake. After taking age, sex, and energy intake into account, participants with the greatest dietary calcium intake had 84% lower odds of glioma than those with the lowest intake [odds ratio (OR): 0.16; 95% confidence interval (CI), 0.07-0.37]. Further adjustment for other potential confounders including nutrient intakes did not significantly alter the association (OR: 0.22; 95% CI, 0.08-0.64). Even after additional adjustment for BMI, we found a significant inverse association between dietary calcium intake and odds of glioma (OR: 0.23; 95% CI, 0.08-0.65). We found an inverse protective association between high dietary calcium intake and odds of glioma. Further prospective cohort studies are needed to confirm these findings. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
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