Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Isfahan Twins Registry (Itr): An Invaluable Platform for Epidemiological and Epigenetic Studies: Design and Methodology of Itr Publisher Pubmed



Gharipour M1 ; Haghjooy Javanmard S2 ; Mansourian M3 ; Sabri M4 ; Khosravi E5 ; Dianatkhah M6 ; Sadeghian L7 ; Jabarzare Z1 ; Sarrafzadegan N1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan Univ. of Medical Sci., Isfahan, Iran
  5. 5. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Cardiac Intervention Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Twin Research and Human Genetics Published:2019


Abstract

Twin studies are one of the main tools for studying the interaction between genes and the environment in the development of complex diseases such as cancers, cardiovascular diseases and diabetes. The Isfahan Twin Registry (ITR) was launched in Isfahan in 2017 as a pilot study to establish a nationwide twin registry in Iran and aims to obtain comprehensive information about complex diseases and their risk factors from twins and multiples living in Isfahan. ITR will continue to recruit twins and multiples until all twins residing in Isfahan are registered in the registry. Twins are identified from welfare agencies, public health homes, maternity hospitals, Persian Twins Association and the local media. Demographic information, twin similarities, lifestyle, family history of diseases and past medical history are collected using validated questionnaires. Anthropometric measurements and blood pressure are measured by health professionals. Hematology panel, fasting blood sugar, total cholesterol, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase, alanine aminotransferase and quantitative C-reactive protein are measured by an automated analyzer. Extra samples are obtained for future studies. For twins aged under 6 years, parents complete the questionnaires for their children and a brief questionnaire for themselves. Currently, 998 persons (395 pairs and 67 multiples) are registered in the ITR and have provided their data. Results of preliminary data analysis are discussed in this article. We plan to carry out longitudinal assessments. ITR can play an important role in future epigenetic, biomarkers and omics studies using the biobank materials. © The Author(s) 2020.
Related Docs
View other Related Docs
1. Isfahan Twin Cohort: A Ten-Year Longitudinal Prospective Study Based on a Twin Registry, ARYA Atherosclerosis (2023)
2. How Do Genetic and Environmental Factors Influence Cardiometabolic Risk Factors? Findings From the Isfahan Twins Study, Journal of Research in Health Sciences (2024)
3. Changes in Immune Profile Affect Disease Progression in Hepatocellular Carcinoma, International Journal of Immunopathology and Pharmacology (2022)
4. Barriers to Home-Based Palliative Care in People With Cancer: A Qualitative Study of the Perspective of Caregivers, Nursing Open (2020)
5. Review of Hepatocellular Carcinoma and Liver Disease Prevalence, New Emirates Medical Journal (2024)
6. Death Portrait of Isfahan Province in Years 2007-2011, International Journal of Preventive Medicine (2016)
7. Prevalence of Metabolic Syndrome and Its Components in the Iranian Adult Population: A Systematic Review and Meta-Analysis, Iranian Red Crescent Medical Journal (2015)
8. The Frequency of Neonatal Outcomes in Multiple Birth in Alzahra and Shahid Beheshti Hospitals, Isfahan, Iran, in 2017, Journal of Isfahan Medical School (2017)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (13)
Roya Kelishadi (9)
Other Related Docs
9. Maternal or Paternal History: Which One Plays More Important Role in Developing Hypertension?, ARYA Atherosclerosis (2022)
10. Genetic Polymorphisms of Y-Chromosome Short Tandem Repeats (Y-Strs) in a Male Population From Golestan Province, Iran, Molecular Biology Research Communications (2020)
11. Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis, Frontiers in Nutrition (2022)
12. The Isfahan Cohort Study: Rationale, Methods and Main Findings, Journal of Human Hypertension (2011)
13. Estimation of Burden of Ischemic Heart Diseases in Isfahan, Iran, 2014: Using Incompleteness and Misclassification Adjustment Models, Journal of Diabetes and Metabolic Disorders (2017)
14. Comparison of Renal Artery Doppler Parameters of Monochorionic Diamniotic Twin Pregnancies With and Without Twin-To-Twin Transfusion Syndrome, Journal of Research in Medical Sciences (2023)
15. Effect of the Number of Negative Lymph Nodes Removed on the Survival and Recurrence Rate After Primary Surgery in Patients With Ovarian Cancer: A Multi-Center Retrospective Cohort Study, Indian Journal of Surgical Oncology (2024)
16. Interaction of Lipoprotein Lipase Polymorphisms With Body Mass Index and Birth Weight to Modulate Lipid Profiles in Children and Adolescents: The Caspian-Iii Study; [Interacao De Polimorfismos Da Lipoproteina Lipase Com Indice De Massa Corporal E Peso Ao Nascer Para Modular O Perfil Lipidico Em Criancas E Adolescentes: O Estudo Caspian-Iii], Sao Paulo Medical Journal (2016)
17. A Systematic Review on the Prevalence of Metabolic Syndrome in Iranian Children and Adolescents, Journal of Research in Medical Sciences (2016)
18. Determining Genetic Variants in Children and Adolescents Suffering From Tetralogy of Fallot With a Positive Family History: Methodology, Acta Biomedica (2020)
19. Impact of Metabolic Syndrome on Ischemic Heart Disease - a Prospective Cohort Study in an Iranian Adult Population: Isfahan Cohort Study, Nutrition, Metabolism and Cardiovascular Diseases (2012)
20. Nationwide Survey of Prevalence and Risk Factors of Prehypertension and Hypertension in Iranian Adults, Journal of Hypertension (2008)
21. Sex Based Levels of C-Reactive Protein and White Blood Cell Count in Subjects With Metabolic Syndrome: Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2013)
22. Ethnic Disparities of the Metabolic Syndrome in Population-Based Samples of German and Iranian Adolescents, Metabolic Syndrome and Related Disorders (2010)
23. Exosomal Micrornas and Long Noncoding Rnas: Novel Mediators of Drug Resistance in Lung Cancer, Journal of Cellular Physiology (2022)
24. Futures of Gastric Cancer: The Fundamental Level of Prevention in Health Promotion Using Casual Layered Analysis, Heliyon (2024)
25. A 10-Year Isfahan Cohort on Cardiovascular Disease As a Master Plan for a Multi-Generation Non-Communicable Disease Longitudinal Study: Methodology and Challenges, Journal of Human Hypertension (2019)
26. Prevalence of Dyslipidemia in Iranian Children and Adolescents: A Systematic Review, Journal of Research in Medical Sciences (2015)
27. Metabolic Risk Factors Attributed Burden in Iran at National and Subnational Levels, 1990 to 2019, Frontiers in Public Health (2023)
28. Determinants of Incident Metabolic Syndrome in a Middle Eastern Population: Isfahan Cohort Study, Metabolic Syndrome and Related Disorders (2017)
29. Does the Impact of Metabolic Syndrome on Cardiovascular Events Vary by Using Different Definitions? Chronic Disease Epidemiology, BMC Public Health (2015)
30. Prevalence of Hypertension in Iran 1980-2012: A Systematic Review, Journal of Tehran University Heart Center (2016)
31. Association of Anthropometric Indices With Cardiovascular Disease Risk Factors Among Children and Adolescents: Caspian Study, International Journal of Cardiology (2007)
32. Genetic and Environmental Influences on Stability and Change in Baseline Levels of C-Reactive Protein: A Longitudinal Twin Study, Atherosclerosis (2017)
33. Socioeconomic Determinants and Metabolic Syndrome: Results From the Isfahan Healthy Heart Program, Acta Biomedica (2016)
34. Cardiovascular Disease Risk Factors, Metabolic Syndrome and Obesity in an Iranian Population, Eastern Mediterranean Health Journal (2008)
35. Determinants of Changes in Metabolic Syndrome Components in a 12-Year Cohort of Iranian Adults, Metabolic Syndrome and Related Disorders (2019)
36. Dietary Intake of Branched-Chain Amino Acids in Relation to the Risk of Breast Cancer, Breast Cancer (2022)
37. The Prospective Epidemiological Research Studies in Iran (Persian) Birth Cohort Protocol: Rationale, Design and Methodology, Longitudinal and Life Course Studies (2021)
38. Multidisciplinary Approach to Functional Somatic Syndromes: Study Protocol for a Population-Based Prospective Cohort Study, BMJ Open (2022)