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Effect of Sesame (Sesamum Indicum L.) Consumption on Glycemic Control in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Ramirezcoronel AA1, 2, 3, 4 ; Ali Alhilali KA5 ; Basheer Ahmed Y6, 7 ; Almalki SG8 ; Karimian J9
Authors
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Authors Affiliations
  1. 1. Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, Catholic University of Cuenca, Azogues Campus Nursing Career, Cuenca, Ecuador
  2. 2. University of Palermo, Buenos Aires, Argentina
  3. 3. Research group in educational statistics, National University of Education, Azogues, Ecuador
  4. 4. Epidemiology and Biostatistics Research Group, CES University, Medellin, Colombia
  5. 5. College of Dentistry, Al-Qadisiyah University, Al-Qadisiyah, Iraq
  6. 6. Clinical Nutrition, University of Hafr Al Batin, Hafar Al Batin, Saudi Arabia
  7. 7. Food science and nutrition, Avinashilingam University, Coimbatore, India
  8. 8. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia
  9. 9. Department of General Courses, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Phytotherapy Research Published:2023


Abstract

Conflicting evidence exists on the effect of sesame consumption on glucose metabolism in patients with type 2 diabetes (T2D). Therefore, this meta-analysis focuses on the relationship between sesame (Sesamum indicum L.) intervention and glycemic control in patients with T2D. Published literature was retrieved and screened from PubMed, Scopus, ISI Web of Science, and the Cochrane Library up to December 2022. Outcome measures included fasting blood sugar (FBS) concentrations, fasting insulin levels, and hemoglobin A1c (HbA1c) percentage. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). Eight clinical trials (395 participants) were eligible for meta-analyses. Overall, sesame consumption significantly reduced serum FBS (WMD: −28.61 mg/dL, 95% CI: −36.07 to −21.16, p˂0.001; I2 = 98.3%) and HbA1c percentage (WMD: −0.99%, 95% CI: −1.22 to −0.76, p ≤ 0.001; I2 = 65.1%) in patients with T2D. However, sesame consumption did not significantly influence fasting insulin levels (Hedges's: 2.29, 95% CI: −0.06 to 4.63, p = 0.06; I2 = 98.1%). In summary, the current meta-analysis showed a promising effect of sesame consumption on glycemic control through reducing FBS and HbA1c, yet additional prospective studies are recommended, using higher doses and longer intervention period, to confirm the impact of sesame consumption on insulin levels in T2D patients. © 2023 John Wiley & Sons Ltd.
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