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The Role of Maternal Tsh Receptor Blocking Antibody in the Etiology of Congenital Hypothyroidism in Isfahan



Abari SS1 ; Hashemipour M2 ; Javanmard SH3 ; Esmaill N4 ; Amini M5 ; Kelishadi R2 ; Hasanzadeh A6
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatrics, Isfahan Endocrine and Metabolism Research Center and Childhood Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Internal Medicine, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Considering the role of maternal TSH receptor blocking Ab (TRAb) in the etioligy of congenital hypothyroidism, the aim of this research was to determine its role among congenital hypothyroidism (CH) in Isfahan. Methods: In this case control study, neonates with CH and their mothers and a group of healthy neonates and their mothers selected as case and control group, respectively. Venous blood samples obtained for the measurement of TRAb. The TSH of mothers was measured also. The prevalence of positive TRAb and the level of TSH were compared between studied groups. Finding: 50 neonates with CH and their mothers and 150 healthy neonates and their mothers studied in case and control groups, respectively. The prevalence of positive TRAb in neonates with CH and their mothers were higher than control group (P < 0.05). There was significant relationship between the TRAb and occurrence of congenital hypothyroidism (P < 0.05). Conclusion: It seems that autoimmunity has an important role in the etiology of congenital hypothyroidism in Isfahan. In order to obtain more conclusive results in these field further studies to determine its role in the etiology of permanent and transient congenital hypothyroidism in accordance with studying other autoantibodies is recommended.
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