Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts

Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts Publisher Pubmed

Avagimyan A¹ ; Fogacci F² ; Pogosova N³ ; Kakturskiy L⁴ ; Jndoyan Z⁵ ; Faggiano A^{6, 7} ; Bairamyan T⁸ ; Agati L⁹ ; Sattar Y¹⁰ ; Mkrchyan L¹¹ ; Avetisyan G²⁹ ; Ginosyan K¹² ; Aznauryan A¹³ ; Sahakyan K¹⁴ Show All Authors

Avagimyan A¹
Fogacci F²
Pogosova N³
Kakturskiy L⁴
Jndoyan Z⁵
Faggiano A^{6, 7}
Bairamyan T⁸
Agati L⁹
Sattar Y¹⁰
Mkrchyan L¹¹
Avetisyan G²⁹
Ginosyan K¹²
Aznauryan A¹³
Sahakyan K¹⁴
Trofimenko A¹⁵
Urazova O¹⁶
Mikhaleva L¹⁷
Vandysheva R¹⁸
Kogan E¹⁹
Demura T²⁰
Kc M²¹
Shafie D²²
Nicola S²³
Brussino L²⁴
Cicero A²⁵
Biondizoccai G^{26, 27}
Sarrafzadegan N^{28, 30}

Show Affiliations

1. MD, PhD, Assistant Professor, Department of Anatomical Pathology and Clinical Morphology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
2. MD, Research Fellow, Atherosclerosis and Metabolic Disorders Research Unit, University of Bologna, Bologna, Italy
3. MD, PhD, Professor, Head of Laboratory of Preventive Cardiology, Deputy Director for Science and Preventive Cardiology, National Medical Research Center of Cardiology named after academician E. Chazov, Moscow, Russian Federation
4. MD, Ph.D, Scientific Director, A. P. Avtsyn Research Institute of Human Morphology of Petrovskiy NRCS, Moscow, Russian Federation
5. MD, PhD, Head of Internal Diseases Propaedeutic Department, Head of Internal Medicine Unit of University Clinical Hospital, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
6. MD, PhD, Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Italy
7. Department of Clinical Sciences and Community Health, University of Milano, Italy
8. MD, PhD, Associate Professor, Department of Rheumatology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
9. MD, PhD, Head of Cardiology Unit Aziendo Umberto II, Department of Cardiology, La Sapienza University of Rome, Rome, Italy
10. MD, Department of Cardiology, West Virginia University, Morgantown, WV, United States
11. MD, PhD, Associate Professor, Department of Cardiology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
12. MD, PhD, Head of Rheumatology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
13. PhD, Associate Professor, Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
14. PhD, Professor, Head of Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
15. MD, PhD, Associate Professor, Department of Pathophysiology, Kuban State Medical University, Krasnodar, Russian Federation
16. MD, PhD, Professor, Head of Pathophysiology Department, Siberian State Medical University, Tomsk, Russian Federation
17. MD, PhD, Director, A. P. Avtsyn Research Institute of Human Morphology of Petrovskiy NRCS, Moscow, Russian Federation
18. MD, PhD, A. P. Avtsyn Research Institute of Human Morphology of Petrovskiy NRCS, Moscow, Russian Federation
19. MD, PhD, Professor, Head of Anatomical Pathology Department, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
20. MD, PhD, Professor, Director of Institute of Clinical Morphology and Digital Pathology, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
21. MD, North Alabama Medical Centre, Florence, AL, United States
22. MD, PhD, Director of Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
23. MD, PhD, Immunology and Allergy Unit, AO Ordine Mauriziano di Torino and Department of Medical Sciences, University of Turin, Italy
24. MD, PhD, Director of the Allergy and Immunology unit AO Ordine Mauriziano di Torino - Department of Medical Sciences, University of Turin, Italy
25. MD, PhD, Professor, Atherosclerosis and Metabolic Disorders Research Unit, University of Bologna, Bologna, Italy
26. MD, PhD, Professor, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
27. Mediterranea Cardiocentro, Napoli, Italy
28. MD, Professor, Director of Isfahan Cardiovascular Research Center (WHO Collaboration Center), Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
29. MD, PhD, Associate Professor, Department of Topographical Anatomy and Operative Surgery, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
30. School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada

Source: Current Problems in Cardiology Published:2024

Abstract

Rheumatoid arthritis (RA) is an idiopathic, autoimmune connective tissue disorder that primarily affects the synovial joints, causing symmetric, erosive-deforming polyarthritis. It is also associated with extra-articular manifestations, particularly cardiovascular (CV) diseases (CVD). CV risk modification in RA remains unsolved despite recent advances in the management of RA. RA is an independent risk factor for atherosclerosis. RA and atherosclerosis share similar pathophysiological features (such as the pro-inflammatory cascade activation including interleukin-6) and risk factors (such as microflora dysbacteriosis and smoking). Patients with RA experience an exacerbation of atherogenesis, with atheromas destabilization, endothelial dysfunction, vasculitis, and hypercytokinemia. Consequently, the inflammatory response associated with RA is the basis for CVD development. The treat-to-target strategy not only improved RA control but also had a favorable effect on the morpho-functional state of the CV system in patients living with RA. Thus, disease-modifying antirheumatic drugs (DMARDs) – in particular methotrexate – may have a beneficial effect on the prevention of CV events in RA. It must be mentioned that RA is a serious multi-system disease, not only because of a window period during which the course of RA can be reversed, but also due to early damage to the heart and blood vessels. For this reason, a thorough cardiological assessment must be performed for all patients with RA, regardless of sex, age, disease stage, and disease activity score. © 2023 Elsevier Inc.

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Style	Citing Format
MLA	Avagimyan A, et al.. "Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts." Current Problems in Cardiology, vol. 49, no. 2, 2024, pp. -.
APA	Avagimyan A, Fogacci F, Pogosova N, Kakturskiy L, Jndoyan Z, Faggiano A, Bairamyan T, Agati L, Sattar Y, Mkrchyan L, Avetisyan G, Ginosyan K, Aznauryan A, Sahakyan K, Trofimenko A, Urazova O, Mikhaleva L, Vandysheva R, Kogan E, ... Sarrafzadegan N (2024). Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts. Current Problems in Cardiology, 49(2), -.
Chicago	Avagimyan A, Fogacci F, Pogosova N, Kakturskiy L, Jndoyan Z, Faggiano A, Bairamyan T, et al.. "Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts." Current Problems in Cardiology 49, no. 2 (2024): -.
Harvard	Avagimyan A et al. (2024) 'Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts', Current Problems in Cardiology, 49(2), pp. -.
Vancouver	Avagimyan A, Fogacci F, Pogosova N, Kakturskiy L, Jndoyan Z, Faggiano A, et al.. Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts. Current Problems in Cardiology. 2024;49(2):-.
BibTex	@article{ author = {Avagimyan A and Fogacci F and Pogosova N and Kakturskiy L and Jndoyan Z and Faggiano A and Bairamyan T and Agati L and Sattar Y and Mkrchyan L and Avetisyan G and Ginosyan K and Aznauryan A and Sahakyan K and Trofimenko A and Urazova O and Mikhaleva L and Vandysheva R and Kogan E and Demura T and Kc M and Shafie D and Nicola S and Brussino L and Cicero A and Biondizoccai G and Sarrafzadegan N}, title = {Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts}, journal = {Current Problems in Cardiology}, volume = {49}, number = {2}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Avagimyan A AU - Fogacci F AU - Pogosova N AU - Kakturskiy L AU - Jndoyan Z AU - Faggiano A AU - Bairamyan T AU - Agati L AU - Sattar Y AU - Mkrchyan L AU - Avetisyan G AU - Ginosyan K AU - Aznauryan A AU - Sahakyan K AU - Trofimenko A AU - Urazova O AU - Mikhaleva L AU - Vandysheva R AU - Kogan E AU - Demura T AU - Kc M AU - Shafie D AU - Nicola S AU - Brussino L AU - Cicero A AU - Biondizoccai G AU - Sarrafzadegan N TI - Methotrexate & Rheumatoid Arthritis Associated Atherosclerosis: A Narrative Review of Multidisciplinary Approach for Risk Modification by the International Board of Experts JO - Current Problems in Cardiology VL - 49 IS - 2 SP - EP - PY - 2024 ER -

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