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A Comprehensive Insight Into Effects of Resveratrol on Molecular Mechanism in Rheumatoid Arthritis: A Literature Systematic Review Publisher Pubmed



Karimi A1, 2 ; Azar PS3 ; Kadkhodayi M4 ; Tandorost A1 ; Vajdi M2, 5 ; Shoorei H6 ; Farhangi MA7
Authors
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Authors Affiliations
  1. 1. Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  3. 3. Department of Nutrition and Hospitality Management, School of Applied Sciences, The University of Mississippi, Mississippi, United States
  4. 4. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  7. 7. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: International Journal of Rheumatic Diseases Published:2022


Abstract

Aim: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, which is characterized by massive pain and destruction of synovial joints, leads to bone erosion, damage to cartilage, and disability. Several studies suggested that resveratrol supplementation may be effective in the prevention and management of RA. Therefore, a systematic review was conducted to summarize published studies that assess the effect of resveratrol supplementation on the complications of RA. Methods: A comprehensive search to identify in vitro, animal, and human studies investigating the impact of resveratrol on the complications of RA was performed up to February 2022. Two independent reviewers evaluated studies based on inclusion/exclusion criteria and performed data extraction. Results: All studies examining the effects of resveratrol supplementation on the complications of RA were included. From a total of 571 retrieved articles, 32 studies were eligible for the current systematic review. The evidence reviewed here indicates that resveratrol supplementation may exert beneficial effects on the complications of RA by attenuating inflammation and oxidative stress, modulating the immune response, and down-regulating the messenger RNA expression of genes related to inflammatory pathways. Conclusion: Due to the promising therapeutic effects of resveratrol on RA complications and limited number of human studies in this subject, further clinical trials are suggested. © 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
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