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Fabrication and Characterization Smart Gold-Polymer Nanostructure As Promising Theranostic Agent for Dual-Imaging and Chemo-Photothermal Therapy of Cancer: An in Vitro Study Publisher



Azizi M1, 2 ; Pakravan A3 ; Valizadeh H4 ; Rahbarghazi R5, 6 ; Dianatmoghadam H7 ; Bani F8 ; Kahroba H9, 10 ; Salehi R11 ; Mehrmohammadi M12, 13, 14
Authors
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Authors Affiliations
  1. 1. Proteomics Research Center, Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Chemistry Department, Faculty of Science, Azerbaijan Shahid Madani University, Tabriz, Iran
  4. 4. Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Toxicogenomics, GROW School for Oncology and Department Biology, Maastricht University, Netherlands
  10. 10. Center for Environmental Science, Hasselt University, Hasselt, Belgium
  11. 11. Drug Applied Research Center and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  12. 12. Department of Imaging Sciences, University of Rochester Medical Center, United States
  13. 13. Department of Biomedical Engineering, University of Rochester, United States
  14. 14. Wilmot Cancer Institute, University of Rochester Medical Center, United States

Source: Journal of Photochemistry and Photobiology A: Chemistry Published:2024


Abstract

In order to enhance the effectiveness of cancer therapy, it is essential to have highly sensitive imaging techniques that provide accurate results and the selection of appropriate therapeutic strategies. Despite recent advances in technologies associated with tumor imaging, the application of conventional single-mode imaging is the subject of debate. Herein, we strategically engineered a nanostructure (GNSs-MTX@CD-Pol) designed from a pH-responsive polymer (Pol), gold nanostar (GNSs), carbon dot (CD), and methotrexate (MTX) as a theranostic agent for simultaneously fluorescent (FI) and X-ray computed tomography (CT) imaging and combination Chemo-Photothermal Therapy in response to near-infrared (NIR) laser irradiation. GNSs-MTX@CD-Pol NPs possess excellent photothermal conversion efficiency and dual FI/CT imaging properties, which are attributed to the strong NIR absorption and high atomic number of gold elements. Moreover, it is demonstrated that GNSs-MTX@CD-Pol NPs are effectively responding to tumor acidity. With the PTT, the growth of cancer cells can be remarkably ablated in vitro. The results of the cell cycle, apoptosis, real-time PCR, and western blotting test on MDA-MB-231 cells revealed antitumor effect of GNSs-MTX@CD-Pol NPs caused by combination Chemo-Photothermal Therapy. Based on their high stability and excellent biocompatibility, GNSs-MTX@CD-Pol NPs have great potential for the treatment of various types of tumors. © 2024 Elsevier B.V.
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