Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection Publisher



Aminolroayaei F1 ; Shahbazigahrouei D1 ; Rostami M2 ; Hejazi SH3 ; Farzadniya A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Novel Drug Delivery Systems Research Centre and Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. Department of Radiology, Askarieh Hospital, Isfahan, 81997-53966, Iran

Source: Micromachines Published:2023


Abstract

Polyoxometalates (POMs) are mineral nanoclusters with many advantages in various diagnostic fields, in particular cancer detection. This study aimed to synthesize and evaluate the performance of gadolinium–manganese–molybdenum polyoxometalate (Gd-Mn-Mo; POM) nanoparticles coated with chitosan–imidazolium (POM@CSIm NPs) for detecting 4T1 breast cancer cells by magnetic resonance imaging in vitro and in vivo. The POM@Cs-Im NPs were fabricated and characterized by FTIR, ICP-OES, CHNS, UV–visible, XRD, VSM, DLS, Zeta potential, and SEM. Cytotoxicity, cellular uptake, and MR imaging in vivo and in vitro of L929 and 4T1 cells were also assessed. The efficacy of nanoclusters was demonstrated using MR images of BALB/C mice bearing a 4T1 tumor in vivo. The evaluation of the in vitro cytotoxicity of the designed NPs showed their high biocompatibility. In fluorescence imaging and flow cytometry, NPs had a higher uptake rate by 4T1 than L929 (p < 0.05). Furthermore, NPs significantly increased the signal strength of MR images, and its relaxivity (r1) was calculated as 4.71 mM−1 s−1. MR imaging also confirmed the attachment of nanoclusters to cancer cells and their selective accumulation in the tumor region. Overall, the results showed that fabricated POM@CSIm NPs have considerable potential as an MR imaging nano-agent for early 4T1 cancer detection. © 2023 by the authors.
Related Docs
View other Related Docs
1. Polyoxometalates As Next-Generation of Theragnostic Gadgets in Cancer, Reviews in Inorganic Chemistry (2024)
2. Anderson-Type Manganese Polyoxomolybdate Hybrid Nanocomposite for Boosting Drug Delivery Against Breast Cancer, Journal of Drug Delivery Science and Technology (2023)
3. Porphyrin–Iron Oxide Nanoparticle Functionalized With Trastuzumab (Ion–Pp–Tz) Potential Mr Imaging Probe for Breast Cancer Cells, Applied Physics A: Materials Science and Processing (2022)
4. Assessment of Manganese-Zinc Ferrite Nanoparticles As a Novel Magnetic Resonance Imaging Contrast Agent for the Detection of 4T1 Breast Cancer Cells, Journal of Medical Signals and Sensors (2019)
5. A Theranostic System Based on Nanocomposites of Manganese Oxide Nanoparticles and a Ph Sensitive Polymer: Preparation, and Physicochemical Characterization, Bioelectrochemistry (2019)
6. A Drug Delivery System Based on Nanocomposites Constructed From Metal-Organic Frameworks and Mn3o4 Nanoparticles: Preparation and Physicochemical Characterization for Bt-474 and Mcf-7 Cancer Cells, Colloids and Surfaces B: Biointerfaces (2021)
7. Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells, Journal of Inorganic and Organometallic Polymers and Materials (2024)
8. Assessment of Superparamagnetic Iron Oxide Nanoparticles Conjugated With Anti-Epidermal Growth Factor Receptor Antibody for the Detection of Lung Cancer by Magnetic Resonance Imaging (Mri) in C57bl/6, Journal of Isfahan Medical School (2021)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (32)
Jaleh Varshosaz (15)
Other Related Docs
9. In Vivo Study of Anti-Epidermal Growth Factor Receptor Antibody-Based Iron Oxide Nanoparticles (Anti-Egfr-Spions) As a Novel Mr Imaging Contrast Agent for Lung Cancer (Llc1) Cells Detection, IET Nanobiotechnology (2020)
10. Arsenic Polyoxotungstate-Zeolitic Imidazolate Framework-8 As a Potential Selective Anti-Cancer Nano Platform, Journal of Inorganic and Organometallic Polymers and Materials (2023)
11. Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and in Vitro Cytotoxicity Evaluations, Langmuir (2021)
12. Detection of Muc1-Expressing Ovarian Cancer by C595 Monoclonal Antibody-Conjugated Spions Using Mr Imaging, The Scientific World Journal (2013)
13. Imaging and Therapeutic Capabilities of the Aunps@Mnco3/Mn3o4, Coated With Paa and Integrated With Folic Acid, Doxorubicin and Propidium Iodide for Murine Breast Cancer, Journal of Drug Delivery Science and Technology (2022)
14. Fabrication of a Biocompatible & Biodegradable Targeted Theranostic Nanocomposite With Ph-Controlled Drug Release Ability, Journal of Drug Delivery Science and Technology (2022)
15. Eco-Friendly and Sustainable Synthesis of Biocompatible Nanomaterials for Diagnostic Imaging: Current Challenges and Future Perspectives, Green Chemistry (2020)
16. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
17. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
18. Therapeutic Effect of Deferrioxamine Conjugated to Pegylated Gold Nanoparticles and Complexed With Mn(Ii) Beside the Ct Scan and Mri Diagnostic Studies, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2019)
19. Investigation of Combination Effect Between 6 Mv X-Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U87-Mg Cancer Cells, Journal of Biomedical Physics and Engineering (2020)
20. Radioprotective Effect of Selenium Nanoparticles: A Mini Review, IET Nanobiotechnology (2024)
21. Evaluation of Anticancer Effects of Cerium Oxide Nanoparticles on Mouse Fibrosarcoma Cell Line, Journal of Cellular Physiology (2019)
22. Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review, ACS Applied Nano Materials (2022)
23. Mxenes in Photomedicine: Advances and Prospects, Chemical Communications (2022)
24. Recent Progress in Cancer Immunotherapy: Application of Nano-Therapeutic Systems, Journal of Drug Delivery Science and Technology (2024)
25. Mesoporous Silica@Chitosan@Gold Nanoparticles As “On/Off” Optical Biosensor and Ph-Sensitive Theranostic Platform Against Cancer, International Journal of Biological Macromolecules (2022)
26. Facile, Rapid and Efficient Isolation of Circulating Tumor Cells Using Aptamer-Targeted Magnetic Nanoparticles Integrated With a Microfluidic Device, RSC Advances (2022)
27. Novel Tocopherol Succinate-Polyoxomolybdate Bioconjugate As Potential Anti-Cancer Agent, Journal of Inorganic and Organometallic Polymers and Materials (2021)
28. A Rapid and Simple Method for Simultaneous Determination of Three Breast Cancer Related Micrornas Based on Magnetic Nanoparticles Modified With S9.6 Antibody, Analytical Biochemistry (2023)
29. Hollow Mesoporous Prussian Blue Nanoparticles for in Vivo Synergistic Chemo-Photothermal Cancer Therapy and Dual-Mode Magnetic Resonance/Fluorescence Imaging, ACS Applied Nano Materials (2024)
30. Mxenes for Cancer Therapy and Diagnosis: Recent Advances and Current Challenges, ACS Biomaterials Science and Engineering (2021)
31. Construction and Characterization of a Theranostic System Based on Graphene/Manganese Chelate, Biosensors and Bioelectronics (2018)
32. Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer, Pharmaceutical Development and Technology (2017)
33. Mxenes and Mxene-Based Materials With Cancer Diagnostic Applications: Challenges and Opportunities, Comments on Inorganic Chemistry (2022)
34. Boron Phenyl Alanine Targeted Chitosan–Pnipaam Core–Shell Thermo-Responsive Nanoparticles: Boosting Drug Delivery to Glioblastoma in Bnct, Drug Development and Industrial Pharmacy (2021)
35. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
36. Folate-Graphene Chelate Manganese Nanoparticles As a Theranostic System for Colon Cancer Mr Imaging and Drug Delivery: In-Vivo Examinations, Journal of Drug Delivery Science and Technology (2019)
37. Anti-Cancer Activity of Biotin-Polyoxomolybdate Bioconjugate, Eurasian Journal of Medicine and Oncology (2020)
38. Biodegradable and Biocompatible Subcutaneous Implants Consisted of Ph-Sensitive Mebendazole-Loaded/Folic Acid-Targeted Chitosan Nanoparticles for Murine Triple-Negative Breast Cancer Treatment, Journal of Nanobiotechnology (2022)
39. Preparation and Cytotoxic Evaluation of Magnetite (Fe3o4) Nanoparticleon Breast Cancer Cells and Its Combinatory Effects With Doxorubicin Used in Hyperthermia, Avicenna Journal of Medical Biotechnology (2013)
40. Tio2 Nanotubes/Reduced Go Nanoparticles for Sensitive Detection of Breast Cancer Cells and Photothermal Performance, Talanta (2020)
41. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
42. Mn(Ii) & Gd(Iii) Deferrioxamine Complex Contrast Agents & Temozolomide Cancer Prodrug Immobilized on Folic Acid Targeted Graphene/Polyacrylic Acid Nanocarrier: Mri Efficiency, Drug Stability & Interactions With Cancer Cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
43. Novel Mr Imaging Nanoprobe for Hepatocellular Carcinoma Detection Based on Manganese–Zinc Ferrite Nanoparticles: In Vitro and in Vivo Assessments, Journal of Cancer Research and Clinical Oncology (2023)
44. Hierarchical Multifunctional Graphene Oxide Cancer Nanotheranostics Agent for Synchronous Switchable Fluorescence Imaging and Chemical Therapy, Microchimica Acta (2020)
45. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
46. Recent Advances in Nanomaterials Development for Nanomedicine and Cancer, ACS Applied Bio Materials (2021)
47. Targeted Delivery of Doxorubicin to Breast Cancer Cells by Magnetic Lhrh Chitosan Bioconjugated Nanoparticles, International Journal of Biological Macromolecules (2016)
48. Mtx-Loaded Dual Thermoresponsive and Ph-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer, Molecular Pharmaceutics (2021)
49. Novel Nanoscale Vanillin Based Covalent Triazine Framework As a Novel Carrier for Sustained Release of Imatinib, Polymers for Advanced Technologies (2023)
50. Her-2 Aptamer-Targeted Ecoflex® Nanoparticles Loaded With Docetaxel Promote Breast Cancer Cells Apoptosis and Anti-Metastatic Effect, IET Nanobiotechnology (2019)