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The Circadian Clock As a Potential Biomarker and Therapeutic Target in Pancreatic Cancer Publisher Pubmed



Pourali G1 ; Ahmadzade AM2, 11 ; Arastonejad M3 ; Pourali R4 ; Kazemi D5 ; Ghasemirad H6 ; Khazaei M1, 7 ; Fiuji H1 ; Nassiri M7 ; Hassanian SM1, 7 ; Ferns GA8 ; Avan A1, 10, 12, 13
Authors
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Authors Affiliations
  1. 1. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States
  4. 4. Student Research Committee, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
  5. 5. Student Research Committee, Isfahan University of Medical Sciences, Hezar Jerib Street, Isfahan, Iran
  6. 6. Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Division of Medical Education, Brighton & amp
  9. 9. Sussex Medical School, Sussex, Falmer, Brighton, BN1 9PH, United Kingdom
  10. 10. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Department of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Brisbane, 4059, QLD, Australia
  13. 13. Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, QLD, Australia

Source: Molecular and Cellular Biochemistry Published:2024


Abstract

Pancreatic cancer (PC) has a very high mortality rate globally. Despite ongoing efforts, its prognosis has not improved significantly over the last two decades. Thus, further approaches for optimizing treatment are required. Various biological processes oscillate in a circadian rhythm and are regulated by an endogenous clock. The machinery controlling the circadian cycle is tightly coupled with the cell cycle and can interact with tumor suppressor genes/oncogenes; and can therefore potentially influence cancer progression. Understanding the detailed interactions may lead to the discovery of prognostic and diagnostic biomarkers and new potential targets for treatment. Here, we explain how the circadian system relates to the cell cycle, cancer, and tumor suppressor genes/oncogenes. Furthermore, we propose that circadian clock genes may be potential biomarkers for some cancers and review the current advances in the treatment of PC by targeting the circadian clock. Despite efforts to diagnose pancreatic cancer early, it still remains a cancer with poor prognosis and high mortality rates. While studies have shown the role of molecular clock disruption in tumor initiation, development, and therapy resistance, the role of circadian genes in pancreatic cancer pathogenesis is not yet fully understood and further studies are required to better understand the potential of circadian genes as biomarkers and therapeutic targets. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.
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